| Dystonin transcripts are altered and their levels are reduced in the mouse neurological mutant dt24J. | |
| | |
MedLine Citation:
|
PMID: 8714679 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Dystonia musculorum is a hereditary mouse neurodegenerative disorder that primarily affects the sensory arm of the nervous system. We have recently cloned and identified a candidate gene for this disorder and designated it dystonin. The sequence of dystonin predicts a rod-shaped cytoskeletal-associated protein with an actin-binding domain at the N-terminal end and a hemidesmosomal protein sequence (bpag1) at the C-terminal end. Here we show that abnormal dystonin transcripts are present in neural tissues of a spontaneous dystonia musculorum mutant, dt24J. We further show that dystonin transcript levels are reduced 2- to 3-fold in dt24J mice. |
| | |
Authors:
|
G Bernier; A Brown; G Dalpé; M Mathieu; Y De Repentigny; R Kothary |
Related Documents
:
|
22317069 - Prevalence of low back disorders among female workers and biomechanical limits on the h... 22146579 - Differential responses of primary auditory cortex in autistic spectrum disorder with au... 3315239 - Autoimmune pathogenesis of paraneoplastic neurological syndromes. 21566419 - Distinguishing symptoms of adhd from other psychiatric disorders in the adult primary c... 22754669 - Microrna from tuberculosis rna: a bioinformatics study. 22833309 - Reduced prefrontal hemodynamic response in pediatric obsessive-compulsive disorder as m... 2259709 - Are there differences in the course of delusional disorders in different periods of time? 19274619 - Coping strategies in eating disorders. 17587879 - Chronic myeloproliferative disorders: the role of tyrosine kinases in pathogenesis, dia... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Biochemistry and cell biology = Biochimie et biologie cellulaire Volume: 73 ISSN: 0829-8211 ISO Abbreviation: Biochem. Cell Biol. Publication Date: 1995 Sep-Oct |
Date Detail:
|
Created Date: 1996-10-04 Completed Date: 1996-10-04 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8606068 Medline TA: Biochem Cell Biol Country: CANADA |
Other Details:
|
Languages: eng Pagination: 605-9 Citation Subset: IM |
Affiliation:
|
Centre de Recherche L.-C. Simard, Institut du cancer de Montréal, QC, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Carrier Proteins* Cytoskeletal Proteins / genetics* Mice Mice, Neurologic Mutants Mice, Transgenic Nerve Tissue Proteins / genetics* Protein Structure, Tertiary RNA, Messenger / genetics*, metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Carrier Proteins; 0/Cytoskeletal Proteins; 0/Dst protein, mouse; 0/Nerve Tissue Proteins; 0/RNA, Messenger |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Changes in retinal ganglion cell axons after optic nerve crush: neurofilament expression is not the ...
Next Document: Overexpression of human keratin 16 produces a distinct skin phenotype in transgenic mouse skin.