Document Detail

Dystonia in AIDS: report of four cases.
MedLine Citation:
PMID:  14673886     Owner:  NLM     Status:  MEDLINE    
Dystonia is a rare complication of acquired immune deficiency syndrome (AIDS). We report four such cases related to three different causes. Cases 1 and 2 both developed dystonia secondary to biopsy-proven progressive multifocal leukoencephalopathy. One had left arm dystonia, whereas the other had bilateral upper limb dystonia. One patient had associated akinesia and rigidity. Imaging demonstrated frontal and/or parietal white matter lesions but no basal ganglia abnormalities. Case 3 developed hemidystonia and cervical dystonia from biopsy-proven toxoplasmosis with a lesion in the thalamus. Case 4 suffered from AIDS dementia complex and developed cervical dystonia while taking risperidone therapy. We also review previously reported cases of dystonia in AIDS patients with the same causes and discuss the issue of increased vulnerability of the basal ganglia to HIV infection which, in turn, leads to increased sensitivity to neuroleptics. When dystonia is seen in AIDS patients, its pattern may be a clue to the ultimate cause.
Stewart A Factor; Michelle Troche-Panetto; Susan A Weaver
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  18     ISSN:  0885-3185     ISO Abbreviation:  Mov. Disord.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-15     Completed Date:  2004-04-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1492-8     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Movement Disorder Society
Albany Medical Center, Department of Neurology, Albany, New York 12205, USA.
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MeSH Terms
Acquired Immunodeficiency Syndrome / complications*,  pathology*
Brain / pathology*
Dystonia / diagnosis*,  etiology*
Frontal Lobe / pathology
Leukoencephalopathy, Progressive Multifocal / etiology,  pathology
Magnetic Resonance Imaging
Parietal Lobe / pathology
Severity of Illness Index
Thalamus / pathology
Toxoplasmosis, Cerebral / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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