Document Detail

Dystonia and akinesia due to pallidoputaminal lesions after disulfiram intoxication.
MedLine Citation:
PMID:  2057009     Owner:  NLM     Status:  MEDLINE    
A case with segmental cranial plus crural dystonia of delayed onset and akinesia after acute intoxication with disulfiram is presented. Computed tomography showed bilateral pallidal lesions, whereas on magnetic resonance imaging additional small lesions of the putamen could be detected. Long-term observation with progression and a change of symptoms over a period of 10 years after the intoxication is demonstrated on videotape. Although other central side effects after intoxication with disulfiram are well known, movement disorders are uncommon. Carbon disulfide, a disulfiram metabolite, may be important in the etiopathogenesis.
J K Krauss; M Mohadjer; A K Wakhloo; F Mundinger
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  6     ISSN:  0885-3185     ISO Abbreviation:  Mov. Disord.     Publication Date:  1991  
Date Detail:
Created Date:  1991-08-01     Completed Date:  1991-08-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  166-70     Citation Subset:  IM    
Department of Neurosurgery, Albert-Ludwigs-Universität, Freiburg, Germany.
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MeSH Terms
Alcoholism / rehabilitation
Disulfiram / poisoning*,  therapeutic use
Dose-Response Relationship, Drug
Dyskinesia, Drug-Induced / pathology*
Dystonia / chemically induced*,  pathology
Globus Pallidus / drug effects*,  pathology
Magnetic Resonance Imaging*
Neurologic Examination
Overdose / pathology*
Putamen / drug effects*,  pathology
Suicide, Attempted
Tomography, X-Ray Computed*
Reg. No./Substance:
Comment In:
Mov Disord. 1992;7(2):188   [PMID:  1584243 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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