| Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphoma. | |
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MedLine Citation:
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PMID: 22752304 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The metabolic differences between B-NHL and primary human B cells are poorly understood. Among human B-cell non-Hodgkin lymphomas (B-NHL), primary effusion lymphoma (PEL) is a unique subset that is linked to infection with Kaposi's sarcoma-associated herpesvirus (KSHV). We report that the metabolic profiles of primary B cells are significantly different from that of PEL. Compared with primary B cells, both aerobic glycolysis and fatty acid synthesis (FAS) are up-regulated in PEL and other types of nonviral B-NHL. We found that aerobic glycolysis and FAS occur in a PI3K-dependent manner and appear to be interdependent. PEL overexpress the fatty acid synthesizing enzyme, FASN, and both PEL and other B-NHL were much more sensitive to the FAS inhibitor, C75, than primary B cells. Our findings suggest that FASN may be a unique candidate for molecular targeted therapy against PEL and other B-NHL. |
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Authors:
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Aadra P Bhatt; Sarah R Jacobs; Alex J Freemerman; Liza Makowski; Jeffrey C Rathmell; Dirk P Dittmer; Blossom Damania |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-06-29 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 109 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-07-18 Completed Date: 2012-10-11 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 11818-23 Citation Subset: IM |
Affiliation:
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Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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4-Butyrolactone
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analogs & derivatives,
pharmacology B-Lymphocytes / metabolism* Computational Biology Fatty Acid Synthetase Complex / antagonists & inhibitors Fatty Acids / biosynthesis* Glycolysis / physiology* Humans Immunoblotting Lymphoma, B-Cell / metabolism* Lymphoma, Primary Effusion / metabolism* Metabolic Networks and Pathways / physiology* Models, Biological Phosphatidylinositol 3-Kinases / metabolism Proto-Oncogene Proteins c-akt / metabolism Signal Transduction / physiology* TOR Serine-Threonine Kinases / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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AA017376/AA/NIAAA NIH HHS; CA096500/CA/NCI NIH HHS; CA123350/CA/NCI NIH HHS; CA163217/CA/NCI NIH HHS; DE018304/DE/NIDCR NIH HHS; DK056350/DK/NIDDK NIH HHS; ES019472/ES/NIEHS NIH HHS; P30DK034987/DK/NIDDK NIH HHS; R01 CA123350/CA/NCI NIH HHS; R01 CA163217/CA/NCI NIH HHS; T32-AI007419/AI/NIAID NIH HHS; T32-CA071341/CA/NCI NIH HHS; T32-CA09156/CA/NCI NIH HHS; T32AI007151/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/4-methylene-2-octyl-5-oxofuran-3-carboxylic acid; 0/Fatty Acids; 96-48-0/4-Butyrolactone; EC 2.7.1.-/Phosphatidylinositol 3-Kinases; EC 2.7.1.1/MTOR protein, human; EC 2.7.1.1/TOR Serine-Threonine Kinases; EC 2.7.11.1/Proto-Oncogene Proteins c-akt; EC 6.-/Fatty Acid Synthetase Complex |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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