Document Detail

Dysregulation of angiotensin II synthesis is associated with salt sensitivity in the spontaneous hypertensive rat.
MedLine Citation:
PMID:  11906319     Owner:  NLM     Status:  MEDLINE    
(1) Salt sensitive hypertension, which occurs as a result of treatment with nitric oxide synthase inhibitors, is associated with a loss of the usual down-regulatory effect of dietary sodium on angiotensin II (Ang II) synthesis. In the spontaneous hypertensive rat (SHR), which suffers a relative NO deficiency, the hypertension is in part salt sensitive. We sought to determine therefore whether the salt sensitive component to the hypertension was associated with a loss of the regulatory effect of dietary sodium on Ang II synthesis. (2) Male SHR were placed on low, intermediate or high salt diets for 4 weeks and their blood pressure recorded. After 4 weeks, blood was collected for determination of renin, angiotensinogen, Ang I, Ang II and aldosterone concentrations, as well as ACE activity. (3) The increase in systolic blood pressure in rats on the high salt diet was significantly greater than in those on the low (P < 0.005) and intermediate salt diets (P < 0.0005). Plasma renin and aldosterone concentrations and ACE activity decreased with increasing dietary sodium. However, the concentrations of Ang II and angiotensinogen both increased in the rats on the high salt diet (Ang II: P < 0.05; angiotensinogen: P < 0.05). (4) We conclude that the hypertension in the SHR is in part salt sensitive and that this salt sensitive component is associated with a loss of the normal down-regulatory effect of dietary sodium on Ang II and angiotensinogen synthesis.
G Hodge; V Z C Ye; K A Duggan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  174     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-21     Completed Date:  2002-06-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  England    
Other Details:
Languages:  eng     Pagination:  209-15     Citation Subset:  IM    
Hypertension Service, South-Western Sydney Clinical School, University of New South Wales, Bankstown, NSW, Australia.
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MeSH Terms
Aldosterone / blood
Angiotensin I / blood
Angiotensin II / biosynthesis*,  blood
Angiotensin-Converting Enzyme Inhibitors / pharmacology
Angiotensinogen / blood
Blood Pressure / drug effects
Hypertension / enzymology,  physiopathology*
Losartan / pharmacology
Peptidyl-Dipeptidase A / blood,  metabolism
Rats, Inbred SHR
Receptors, Angiotensin / antagonists & inhibitors,  metabolism
Renin / blood
Sodium Chloride, Dietary / administration & dosage,  pharmacology*
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Receptors, Angiotensin; 0/Sodium Chloride, Dietary; 11002-13-4/Angiotensinogen; 11128-99-7/Angiotensin II; 114798-26-4/Losartan; 52-39-1/Aldosterone; 9041-90-1/Angiotensin I; EC A; EC

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