| Dysregulation of aldosterone secretion and its relationship to the pathogenesis of essential hypertension. | |
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MedLine Citation:
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PMID: 1879402 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The level of sodium intake has a reciprocal influence on the vascular and adrenal responses to angiotensin II, with sodium restriction enhancing the adrenal responses and reducing vascular, and particularly renal vascular, responses. In two subgroups of the essential hypertensive population, this relationship is abnormal. Both subgroups have sodium-sensitive hypertension. One is a subset of the low renin essential hypertensive subgroup and its abnormality is an enhanced aldosterone response to angiotensin II with sodium loading, ie, a failure to down-regulate the aldosterone response. The other subgroup, termed nonmodulators, is a subset of the normal-high renin essential hypertensive subgroup. In these patients, sodium intake modifies either adrenal or vascular responses, including renal vascular responses, to angiotensin II--resulting in a reduced aldosterone response to angiotensin II with sodium restriction. Of clinical importance, the nonmodulator's abnormality is corrected by the administration of converting enzyme inhibitors--this class of drugs therefore being a specific form of therapy in these patients. |
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Authors:
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G H Williams; T J Moore; N K Hollenberg |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Endocrinology and metabolism clinics of North America Volume: 20 ISSN: 0889-8529 ISO Abbreviation: Endocrinol. Metab. Clin. North Am. Publication Date: 1991 Jun |
Date Detail:
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Created Date: 1991-10-01 Completed Date: 1991-10-01 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8800104 Medline TA: Endocrinol Metab Clin North Am Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 423-47 Citation Subset: IM; S |
Affiliation:
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Department of Medicine, Harvard Medical School, Boston, Massachusetts. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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secretion* Angiotensin II / pharmacology Homeostasis* Humans Hypertension / etiology* Renin / blood Sodium, Dietary / administration & dosage, pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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2 MO1 RR02635/RR/NCRR NIH HHS; HL07609/HL/NHLBI NIH HHS; HL36568/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Sodium, Dietary; 11128-99-7/Angiotensin II; 52-39-1/Aldosterone; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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