Document Detail


Dysregulation of the microvasculature in nonlesional non-sun-exposed skin of patients with lupus nephritis.
MedLine Citation:
PMID:  22298906     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Membrane endothelial protein C receptor (mEPCR) is highly expressed in peritubular capillaries of kidneys from patients with active and poorly responsive lupus nephritis (LN). We investigated the hypothesis that changes in the microvasculature are widespread with extension to the dermal vasculature.
METHODS: Skin biopsies from uninvolved skin (buttocks) were performed in 27 patients with LN and 5 healthy controls. Sections were stained with specific antibodies reactive with mEPCR, adiponectin, intercellular adhesion molecule-1 (ICAM-1), and CD31; then assessed by enumeration of stained blood vessels (percentage positive blood vessels) blinded to knowledge of clinical information.
RESULTS: There was a significant increase in the prevalence of blood vessels that stained for mEPCR and ICAM-1 in patients compared to controls [94% vs 59% (p = 0.045) and 81% vs 67% (p = 0.037), respectively]. Adiponectin staining and CD31 staining were similar between the groups (45% vs 43% and 98% vs 92%). Dermal staining for mEPCR was greater in patients with proliferative glomerulonephritis than in those with membranous disease (96% vs 60%; p = 0.029). A composite of poor prognostic renal markers and death was significantly associated with greater expression of mEPCR staining.
CONCLUSION: These data are consistent with the notion that in patients with LN, activation of the microvasculature extends beyond the clinically targeted organ. The insidious expression of this widespread vasculopathy may be a contributor to longterm comorbidities.
Authors:
Peter M Izmirly; Marianna Shvartsbeyn; Shane Meehan; Andrew Franks; Alan Braun; Ellen Ginzler; Sherry X Xu; Herman Yee; Tania L Rivera; Tania Rivera; Charles Esmon; Laura Barisoni; Joan T Merrill; Jill P Buyon; Robert M Clancy
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-02-01
Journal Detail:
Title:  The Journal of rheumatology     Volume:  39     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-02     Completed Date:  2012-07-26     Revised Date:  2014-06-15    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  510-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adiponectin / metabolism
Adult
Antigens, CD / metabolism
Antigens, CD31 / metabolism
Biological Markers / metabolism
Biopsy
Capillaries / metabolism,  pathology,  physiopathology*
Case-Control Studies
Endothelium, Vascular / metabolism,  pathology,  physiopathology*
Female
Humans
Intercellular Adhesion Molecule-1 / metabolism
Lupus Nephritis / diagnosis,  metabolism,  physiopathology*
Male
Microcirculation / physiology*
Prognosis
Receptors, Cell Surface / metabolism
Skin / blood supply*,  pathology
Grant Support
ID/Acronym/Agency:
R01 AR055088/AR/NIAMS NIH HHS; R01 AR055088-01/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Adiponectin; 0/Antigens, CD; 0/Antigens, CD31; 0/Biological Markers; 0/PROCR protein, human; 0/Receptors, Cell Surface; 126547-89-5/Intercellular Adhesion Molecule-1
Comments/Corrections
Erratum In:
J Rheumatol. 2012 Apr;39(4):881
Note: Rivera, Tania [corrected to Rivera, Tania L]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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