Document Detail


Dysregulated Th1 and Th2 responses in food-allergic children--does elimination diet contribute to the dysregulation?
MedLine Citation:
PMID:  20636896     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Infants with eczema and sensitization to foods are recommended skin care and, if food allergy is proven, an elimination diet. Although most of these children tolerate foods before 3 yr of age, some children experience prolonged food allergy. To our knowledge, no prospective study has investigated the cytokine profile in food-sensitized eczematous children with prolonged food intolerance. The aim of the study was to prospectively investigate the development of cytokine production induced by food allergen in food-sensitized eczematous children who, at 4(1/2) yr of age, were allergic or tolerant to egg or milk. Twenty-one eczematous infants, [age 5 (3-10) months; median and range], sensitized to egg and/or milk were included, put on elimination diet and followed prospectively. At 4(1/2) yr of age, the children were defined as tolerant or allergic to egg and/or milk based on open or double-blind placebo-controlled food challenges. Peripheral blood mononuclear cells (PBMC) were isolated from the children on inclusion, after 6 wk of elimination diet, and at 3 and 4(1/2) yr of age. Ovalbumin, beta-lactoglobulin and tetanus toxoid-induced IL-4, -5, -10, -13 and IFN-gamma production from PBMC were analyzed with enzyme-linked immunosorbent assay. The IFN-gamma and IL-5 secretion induced by food allergen at 4(1/2) yr was higher in cell cultures from children who were allergic to egg or milk than in tolerant children. In food-allergic children, the levels of IFN-gamma and IL-5 were higher at 4(1/2) yr compared with inclusion levels, but this increase was generally not observed in the tolerant children who consumed milk and egg. In conclusion, immune cells from food-allergic children on an elimination diet respond with up-regulated T helper 1 and T helper 2 cytokine secretion induced by food allergen. We hypothesize that allergen elimination may influence the regulatory mechanisms maintaining balanced immune responses to innocuous food antigens.
Authors:
Sara Tomicić; Karin Fälth-Magnusson; Malin Fagerås Böttcher
Related Documents :
2264466 - Use of a test diet in screening for neuroblastoma reduces false-positives attributable ...
11533756 - Prevalence of food allergy in asthmatic patients.
2251976 - Clinical, biochemical and immunological effectiveness of diacetyl-splenopentin (bch 069...
15238206 - Dietary treatment of the irritable bowel syndrome.
21641546 - The circadian clock interacts with metabolic physiology to influence reproductive fitness.
23701046 - Arthropod food webs become increasingly lipid-limited at higher trophic levels.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology     Volume:  21     ISSN:  1399-3038     ISO Abbreviation:  Pediatr Allergy Immunol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-07-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9106718     Medline TA:  Pediatr Allergy Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  649-55     Citation Subset:  IM    
Affiliation:
Division of Pediatrics, Department of Clinical and Experimental Medicine, and Unit of Clinical Experimental Research, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Sublingual immunotherapy in children--ready for prime time?
Next Document:  The risk of generalized allergic reactions to skin prick testing may be higher in poly-sensitized in...