| Dyspraxia in autism: association with motor, social, and communicative deficits. | |
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MedLine Citation:
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PMID: 17880641 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Impaired performance of skilled gestures, referred to as dyspraxia, is consistently reported in children with autism; however, its neurological basis is not well understood. Basic motor skill deficits are also observed in children with autism and it is unclear whether dyspraxia observed in children with autism can be accounted for by problems with motor skills. Forty-seven high-functioning children with an autism spectrum disorder (ASD), autism, or Asperger syndrome (43 males, four females; mean age 10y 7m [SD 1y 10m], mean Full-scale IQ (FSIQ) 99.4 [SD 15.9]), and 47 typically developing (TD) controls (41 males, six females; mean age 10y 6m [SD 1y 5m], mean FSIQ 113.8 [SD 12.3], age range 8-4y) completed: (1) the Physical and Neurological Assessment of Subtle Signs, an examination of basic motor skills standardized for children, and (2) a praxis examination that included gestures to command, to imitation, and with tool-use. Hierarchical regression was used to examine the association between basic motor skill performance (i.e. times to complete repetitive limb movements) and praxis performance (total praxis errors). After controlling for age and IQ, basic motor skill was a significant predictor of performance on praxis examination. Nevertheless, the ASD group continued to show significantly poorer praxis than controls after accounting for basic motor skill. Furthermore, praxis performance was a strong predictor of the defining features of autism, measured using the Autism Diagnostic Observation Schedule, and this correlation remained significant after accounting for basic motor skill. Results indicate that dyspraxia in autism cannot be entirely accounted for by impairments in basic motor skills, suggesting the presence of additional contributory factors. Furthermore, praxis in children with autism is strongly correlated with the social, communicative, and behavioral impairments that define the disorder, suggesting that dyspraxia may be a core feature of autism or a marker of the neurological abnormalities underlying the disorder. |
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Authors:
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M A Dziuk; J C Gidley Larson; A Apostu; E M Mahone; M B Denckla; S H Mostofsky |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Developmental medicine and child neurology Volume: 49 ISSN: 0012-1622 ISO Abbreviation: Dev Med Child Neurol Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-09-20 Completed Date: 2007-11-07 Revised Date: 2013-04-09 |
Medline Journal Info:
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Nlm Unique ID: 0006761 Medline TA: Dev Med Child Neurol Country: England |
Other Details:
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Languages: eng Pagination: 734-9 Citation Subset: IM |
Affiliation:
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University of Texas Health Science Center at San Antonio, Texas, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apraxia, Ideomotor
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diagnosis,
epidemiology,
physiopathology Apraxias / diagnosis, epidemiology*, physiopathology Asperger Syndrome / epidemiology Child Cognition Disorders / diagnosis, epidemiology Communication Disorders / diagnosis, epidemiology* Female Humans Male Mass Screening / methods Motor Skills Disorders / diagnosis, epidemiology* Neuropsychological Tests Observer Variation Prevalence Psychomotor Performance Severity of Illness Index Social Behavior* |
| Grant Support | |
ID/Acronym/Agency:
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K02 NS044850/NS/NINDS NIH HHS; M01 RR00052/RR/NCRR NIH HHS; P30 HD 24061/HD/NICHD NIH HHS; R01 MH078160/MH/NIMH NIH HHS; R01 MH085328/MH/NIMH NIH HHS; R01 NS048527/NS/NINDS NIH HHS; R01 NS048527/NS/NINDS NIH HHS; R01 NS048527-07/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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