Document Detail


Dyspraxia in autism: association with motor, social, and communicative deficits.
MedLine Citation:
PMID:  17880641     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Impaired performance of skilled gestures, referred to as dyspraxia, is consistently reported in children with autism; however, its neurological basis is not well understood. Basic motor skill deficits are also observed in children with autism and it is unclear whether dyspraxia observed in children with autism can be accounted for by problems with motor skills. Forty-seven high-functioning children with an autism spectrum disorder (ASD), autism, or Asperger syndrome (43 males, four females; mean age 10y 7m [SD 1y 10m], mean Full-scale IQ (FSIQ) 99.4 [SD 15.9]), and 47 typically developing (TD) controls (41 males, six females; mean age 10y 6m [SD 1y 5m], mean FSIQ 113.8 [SD 12.3], age range 8-4y) completed: (1) the Physical and Neurological Assessment of Subtle Signs, an examination of basic motor skills standardized for children, and (2) a praxis examination that included gestures to command, to imitation, and with tool-use. Hierarchical regression was used to examine the association between basic motor skill performance (i.e. times to complete repetitive limb movements) and praxis performance (total praxis errors). After controlling for age and IQ, basic motor skill was a significant predictor of performance on praxis examination. Nevertheless, the ASD group continued to show significantly poorer praxis than controls after accounting for basic motor skill. Furthermore, praxis performance was a strong predictor of the defining features of autism, measured using the Autism Diagnostic Observation Schedule, and this correlation remained significant after accounting for basic motor skill. Results indicate that dyspraxia in autism cannot be entirely accounted for by impairments in basic motor skills, suggesting the presence of additional contributory factors. Furthermore, praxis in children with autism is strongly correlated with the social, communicative, and behavioral impairments that define the disorder, suggesting that dyspraxia may be a core feature of autism or a marker of the neurological abnormalities underlying the disorder.
Authors:
M A Dziuk; J C Gidley Larson; A Apostu; E M Mahone; M B Denckla; S H Mostofsky
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental medicine and child neurology     Volume:  49     ISSN:  0012-1622     ISO Abbreviation:  Dev Med Child Neurol     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-20     Completed Date:  2007-11-07     Revised Date:  2013-04-09    
Medline Journal Info:
Nlm Unique ID:  0006761     Medline TA:  Dev Med Child Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  734-9     Citation Subset:  IM    
Affiliation:
University of Texas Health Science Center at San Antonio, Texas, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Apraxia, Ideomotor / diagnosis,  epidemiology,  physiopathology
Apraxias / diagnosis,  epidemiology*,  physiopathology
Asperger Syndrome / epidemiology
Child
Cognition Disorders / diagnosis,  epidemiology
Communication Disorders / diagnosis,  epidemiology*
Female
Humans
Male
Mass Screening / methods
Motor Skills Disorders / diagnosis,  epidemiology*
Neuropsychological Tests
Observer Variation
Prevalence
Psychomotor Performance
Severity of Illness Index
Social Behavior*
Grant Support
ID/Acronym/Agency:
K02 NS044850/NS/NINDS NIH HHS; M01 RR00052/RR/NCRR NIH HHS; P30 HD 24061/HD/NICHD NIH HHS; R01 MH078160/MH/NIMH NIH HHS; R01 MH085328/MH/NIMH NIH HHS; R01 NS048527/NS/NINDS NIH HHS; R01 NS048527/NS/NINDS NIH HHS; R01 NS048527-07/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Epidemiology of autism spectrum disorder in Portugal: prevalence, clinical characterization, and med...
Next Document:  Secondary abnormalities of neurotransmitters in infants with neurological disorders.