Document Detail


Dyspnea and decreased variability of breathing in patients with restrictive lung disease.
MedLine Citation:
PMID:  11991875     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients with restrictive lung disease are typically dyspneic and have an increase in overall respiratory center drive, as a result of increased lung elasticity. When we subjected healthy volunteers to external elastic loads, their variability of breathing was lessened. Accordingly, we hypothesized that patients with restrictive lung disease display decreased variability of breathing and, also, that decreased variability of breathing is related to dyspnea. Breathing pattern was measured nonobtrusively over 1 hour in 10 patients with restrictive lung disease and in 7 healthy subjects. On a separate occasion, dyspnea was measured while all subjects copied different tidal volumes and frequencies. Compared with healthy subjects, the random fraction of breath variability was reduced in patients with restrictive lung disease: 27 times for expiratory time, 12 times for tidal volume, and 6 times for inspiratory time (p < 0.01 in each instance). Conversely, the nonrandom, correlated fraction for tidal volume was increased almost 3-fold in the patients (p < 0.01). Small variations from average resting tidal volume caused marked increases in dyspnea in patients, and the relationship was parabolic (r2 = 0.97; p < 0.001). In conclusion, patients with restrictive lung disease adopt a tightly constrained breathing pattern, probably as a strategy for avoiding dyspnea.
Authors:
Thomas Brack; Amal Jubran; Martin J Tobin
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  165     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-05-06     Completed Date:  2002-06-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1260-4     Citation Subset:  AIM; IM    
Affiliation:
Division of Pulmonary and Critical Care Medicine, Edward Hines Jr., Veterans Affairs Hospital, Hines, Illinois 60141, USA.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Dyspnea / etiology,  physiopathology*
Humans
Lung Diseases / complications,  physiopathology*
Male
Middle Aged
Models, Biological
Pulmonary Fibrosis / physiopathology
Respiration*
Respiratory Mechanics
Sensation
Tidal Volume

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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