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Dyspnea assessment and pulmonary hypertension in patients with systemic sclerosis: Utility of the UCSD Shortness-of-Breath questionnaire.
MedLine Citation:
PMID:  23042670     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: The UCSD Shortness-of-Breath Questionnaire (SOBQ) has been used to assess dyspnea-related activitylimitation in patients with airway and parenchymal lung disease. We sought to assess the constructvalidity and responsiveness of the SOBQ in systemic sclerosis (SSc) patients with incident pulmonary hypertension(PH) and those at high risk for developing PH. METHODS: We used data from 179 patients enrolled in the PHAROS registry with pre-PH, by defined criteria on pulmonary function tests and/or echocardiogram, or definite PH with mean pulmonary artery pressure > 25 mmHg by right heart catheterization within 6 months of enrollment. For this analysis, we included those subjects with complete data for self-reportedmeasures at baseline and 12 months. RESULTS: At baseline the SOBQ had strong correlations in the expected directions with the health assessment questionnaire-disability index (HAQ-DI)(r=0.71, p<.0001), dyspnea assessment by visual analogue scale (r=0.71, p<.0001), and SF-36 physical component score (PCS)(r=-0.77, p<.0001) and a moderate correlation with 6 minute walk distance(r=-0.33, p=.0001), Borg dyspnea score (r=0.47, p<.0001), and diffusing capacity (r=-0.33, p<.0001). Change in SOBQ at 12 months correlated in the expected direction with change in HAQ-DI (r=0.54, p<.0001) and change in SF-36 PCS (r=-0.44, p<.0001). Multivariate analysis adjusting for age, gender, and race identified male gender as a significant predictor of death (OR=7.00, 95% CI 1.55 - 31.76), while the SOBQ showed a strong trend toward significance (OR=1.82, 95% CI 0.97 - 3.41). CONCLUSIONS: The SOBQ demonstrates good construct validity and responsiveness to change in SSc patients with pulmonary vascular disease.
Authors:
Lorinda Chung; Hubert Chen; Dinesh Khanna; Virginia D Steen
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-6
Journal Detail:
Title:  Arthritis care & research     Volume:  -     ISSN:  2151-4658     ISO Abbreviation:  Arthritis Care Res (Hoboken)     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101518086     Medline TA:  Arthritis Care Res (Hoboken)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 by the American College of Rheumatology.
Affiliation:
Stanford University, Stanford, CA; VA Palo Alto Health Care System, Palo Alto, CA. shauwei@stanford.edu.
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