Document Detail


Dyslipidemia among newly diagnosed hypertensives: pattern and clinical correlates.
MedLine Citation:
PMID:  20533775     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Hypertension and dyslipidemia are closely interrelated. We aim to determine the prevalence of dyslipidemia among newly diagnosed Nigerian hypertensive subjects and its associated clinical correlates. MATERIALS AND METHODS: This was a cross-sectional study done at the Ladoke Akintola University of Technology (LAUTECH) Teaching Hospital, Osogbo, southwest Nigeria. One hundred sixty-three newly diagnosed hypertensive subjects and 88 controls were recruited and formed the study groups. Relevant history, examinations, and laboratory investigations were performed. Lipid parameters and atherogenic indices were determined. SPSS 16.0 was used for statistical analysis. RESULTS: Hypertensive subjects and controls were well matched in age and gender distribution. Dyslipidemia was more common among the hypertensive subjects. Ninety-six (58.9%) newly diagnosed hypertensive subjects had at least 1 impaired lipid profile. Sixty-seven (41.1%) of them had isolated dyslipidemia, while 29 (17.8%) had combined dyslipidemia. Common patterns of dyslipidemia include low high-density lipoprotein cholesterol (HDL-C), 78 (47.9%); high atherogenic index (total cholesterol/HDL-C), 40 (24.5%) and elevated low-density lipoprotein cholesterol (LDL-C) in 38 (23.3%) subjects. Fasting blood glucose increased as the severity of dyslipidemia increased. CONCLUSIONS: A significant proportion of newly diagnosed hypertensive subjects have dyslipidemia. Low HDL-C was the most common type of dyslipidemia in this study. The use of statins and other supportive therapy is therefore justified among newly diagnosed Nigerian hypertensive subjects with isolated or combined dyslipidemia.
Authors:
Adeseye A Akintunde; E Olugbenga Ayodele; Olayinka P Akinwusi; George O Opadijo
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of the National Medical Association     Volume:  102     ISSN:  0027-9684     ISO Abbreviation:  J Natl Med Assoc     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-06-10     Completed Date:  2010-07-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503090     Medline TA:  J Natl Med Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  403-7     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Ladoke Akintola University of Technology Teaching Hospital, Osogbo, Nigeria. iakintunde2@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Cross-Sectional Studies
Dyslipidemias / diagnosis,  epidemiology*,  etiology
Female
Humans
Hypertension / blood,  complications,  diagnosis*,  epidemiology
Lipids / blood
Male
Middle Aged
Nigeria / epidemiology
Prevalence
Chemical
Reg. No./Substance:
0/Lipids

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