Document Detail

Dyslipidaemia and hypertension in patients with subclinical hypothyroidism.
MedLine Citation:
PMID:  20087252     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to assess whether subclinical hypothyroidism (SCH) is associated with dyslipidaemia and arterial hypertension. METHODS: At the Department of Endocrinology, Diabetes and Metabolic Disorders, Skopje, R. Macedonia, we examined 24 consecutive patients with SCH and 13 healthy controls in a period of 6 months. SCH was defined as an elevated thyrotropin (TSH) (> 4.2 mU/l) and normal free thyroxine (fT4) level (10.3-24.45 pmol/l). None of the patients had been previously treated with thyroxine. In all participants we determined blood pressure, body mass index (BMI), TSH, fT4, antibodies to thyroid peroxidise (TPOabs), total lipids (TL), total cholesterol (TH), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides. RESULTS: Mean diastolic blood pressure increased in SCH patients vis-a-vis controls (85 vs. 74 mmHg; p < 0.05). Mean values of TL, TH, HDL-C, LDL-C, triglycerides, TC/HDL-C, and LDL-C/HDL-C were no different in patients with SCH compared with controls. Individual analysis revealed that the percentages of patients with SCH having arterial hypertension (29%), hypertriglyceridaemia (34.78%), elevated LDL-C (41.66%), elevated TC/HDL-C (21.7%), and LDL-C/HDL-C (21.74%) ratios were higher than the percentages in controls. No significant correlation between TSH and biochemical parameters was detected. CONCLUSION: Our study revealed that SCH patients have a greater prevalence of dyslipidaemia and arterial hypertension, and, as well, a greater value of mean diastolic pressure vs. control patients.
V Velkoska Nakova; B Krstevska; M Bosevski; Ch Dimitrovski; V Serafimoski
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prilozi / Makedonska akademija na naukite i umetnostite, Oddelenie za biolo?ki i medicinski nauki = Contributions / Macedonian Academy of Sciences and Arts, Section of Biological and Medical Sciences     Volume:  30     ISSN:  0351-3254     ISO Abbreviation:  Prilozi     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2010-01-20     Completed Date:  2010-04-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101189513     Medline TA:  Prilozi     Country:  Macedonia    
Other Details:
Languages:  eng     Pagination:  93-102     Citation Subset:  IM    
Endocrinology, Diabetes and Metabolic Disorders Clinic, Medical Faculty, Skopje, R. Macedonia.
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MeSH Terms
Dyslipidemias / etiology*
Hypertension / etiology*
Hypothyroidism / complications*
Middle Aged

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