Document Detail

Dysfunctional central hemodynamic regulation after daily meal intake in metabolic syndrome.
MedLine Citation:
PMID:  19962146     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Postprandial hyperlipidemia and insulin resistance play roles in the development of atherosclerosis in metabolic syndrome (MetS); however, the clinical significance of postprandial hemodynamic variables in this condition is still in question. The aim of this study was to investigate hemodynamic and metabolic indicators related to MetS after a mixed meal (Calorie mate, 500 kcal). METHODS: Of 107 participants undergoing this investigation, 24 fulfilled ATPIII criteria for MetS. The remaining 83 subjects were controls. Both the augmentation index (AI) and late systolic blood pressure in the radial artery (rSBP2) as an index of central blood pressure were monitored using HEM-9000AI (Omron Healthcare, Kyoto, Japan) until 240 min after meal intake. RESULTS: Both AI and rSBP2 showed significant decreases after meal intake in both groups. Changes in postprandial AI showed a similar trend in the groups. rSBP2 reduction 60 min after meal ingestion was also comparable, -7.5+/-2.3 mmHg in MetS; -7.8+/-0.9 mmHg in control; however, delta rSBP2-120, the degree of rSBP2 reduction 120 min after meal ingestion comparing the fasting level, showed a significant difference between 2 groups, -0.5+/-2.0 mmHg in MetS; -5.3+/-0.9 mmHg in control, P<0.02. Stepwise regression analysis revealed low-density-lipoprotein cholesterol (beta=0.333, P=0.001), high-density-lipoprotein cholesterol (beta=-0.209, P<0.05) and systolic blood pressure (beta=-0.377, P<0.001) as independent variables for determining delta rSBP2-120. CONCLUSION: Subjects with MetS exhibit signs of blunted rSBP2 (=central blood pressure) regulation after food intake. Dysfunctional postprandial hemodynamic regulation is another feature of MetS that may contribute to the progression of cardiovascular disease.
Jun-ichi Funada; Yasunori Takata; Hidetoshi Hashida; Yuji Matsumoto; Sumiko Sato; Go Hiasa; Katsuji Inoue; Jitsuo Higaki; Hideki Okayama
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Publication Detail:
Type:  Journal Article     Date:  2009-11-10
Journal Detail:
Title:  Atherosclerosis     Volume:  210     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-30     Completed Date:  2010-08-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  268-73     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
Department of Cardiology, NHO Ehime National Hospital, 366 Yokogawara, Toon, Ehime, Japan.
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MeSH Terms
Blood Pressure / physiology
Central Venous Pressure / physiology*
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Eating / physiology*
Metabolic Syndrome X / physiopathology*
Middle Aged
Postprandial Period
Radial Artery / physiology
Reg. No./Substance:
0/Cholesterol, HDL; 0/Cholesterol, LDL

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