Document Detail


Dysfunctional high-density lipoprotein and the potential of apolipoprotein A-1 mimetic peptides to normalize the composition and function of lipoproteins.
MedLine Citation:
PMID:  21628835     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although high-density lipoprotein-cholesterol (HDL-C) levels in large epidemiological studies are inversely related to the risk of coronary heart disease (CHD), increasing the level of circulating HDL-C does not necessarily decrease the risk of CHD events, CHD deaths, or mortality. HDL can act as an anti- or a pro-inflammatory molecule, depending on the context and environment. Based on a number of recent studies, it appears that the anti- or pro-inflammatory nature of HDL may be a more sensitive indicator of the presence or absence of atherosclerosis than HDL-C levels. The HDL proteome has been suggested to be a marker, and perhaps a mediator, of CHD. Apolipoprotein A-1 (apoA-I), the major protein in HDL is a selective target for oxidation by myeloperoxidase, which results in impaired HDL function. Improving HDL function through modification of its lipid and/or protein content maybe a therapeutic target for the treatment of CHD and many inflammatory disorders. HDL/apoA-I mimetic peptides may have the ability to modify the lipid and protein content of HDL and convert dysfunctional HDL to functional HDL. This review focuses on recent studies of dysfunctional HDL in animal models and human disease, and the potential of apoA-I mimetic peptides to normalize the composition and function of lipoproteins.
Authors:
Satoshi Imaizumi; Mohamad Navab; Cecilia Morgantini; Christina Charles-Schoeman; Feng Su; Feng Gao; Murray Kwon; Ekambaram Ganapathy; David Meriwether; Robin Farias-Eisner; Alan M Fogelman; Srinivasa T Reddy
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-05-28
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  75     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2011  
Date Detail:
Created Date:  2011-06-24     Completed Date:  2012-01-18     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1533-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Apolipoprotein A-I / physiology*,  therapeutic use
Biomimetics*
Coronary Disease / physiopathology,  prevention & control
Disease Models, Animal
Humans
Lipoproteins, HDL / chemistry,  physiology*
Mice
Peptides / therapeutic use*
Grant Support
ID/Acronym/Agency:
HL-082823/HL/NHLBI NIH HHS; HL-30568/HL/NHLBI NIH HHS; HL-34343/HL/NHLBI NIH HHS; K23 HL094834/HL/NHLBI NIH HHS; P01 HL030568/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Apolipoprotein A-I; 0/D-4F peptide; 0/L-4F peptide; 0/Lipoproteins, HDL; 0/Peptides; 0/peptide 5F
Comments/Corrections

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