| Dysfunction of the magnocellular stream in Alzheimer's disease evaluated by pattern electroretinograms and visual evoked potentials. | |
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MedLine Citation:
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PMID: 20385208 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Visuo-spatial disturbances could represent a clinical feature of early stage Alzheimer's disease (AD). The magnocellular (M) pathway has anatomo-physiological characteristic which make it more suitable for detecting form, motion and depth compared with parvocellular one (P). OBJECTIVE: Aim of our study was to evaluate specific visual subsystem involvement in a group of AD patients, recording isoluminant chromatic and luminance pattern electroretinograms and pattern visual evoked potentials. MATERIAL AND METHODS: data were obtained from 15 AD patients (9 females and 6 males, mean age+/-1SD: 77.6+/-4.01 years) not yet undergoing any treatment, and from 10 age-matched healthy controls. Diagnosis of probable AD was clinically and neuroradiologically established. PERGs were recorded monocularly in response to equiluminant red-green (R-G), blue-yellow (B-Y) and luminance yellow-black (Y-Bk) horizontal square gratings of 0.3c/deg and 90% contrast, reversed at 1Hz. VEPs were recorded in response to full-field (14 deg) equiluminant chromatic R-G, B-Y and luminance Y-Bk sinusoidal gratings of 2c/deg, presented in onset (300ms)-offset (700ms) mode, at the contrast levels of 90%. RESULTS: All data were retrieved in terms of peak-amplitude and latency and assessed using the Student's t-test for paired data. Temporal differences of PERGs and VEPs, evoked by Y-Bk grating in AD patients compared with controls, suggest a specific impairment of the magnocellular stream. CONCLUSIONS: Our study support the hypothesis that the impairment of the PERGs and VEPs arising from the magnocellular streams of visual processing may indicate a primary dysfunction of the M-pathways in AD. |
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Authors:
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F Sartucci; D Borghetti; T Bocci; L Murri; P Orsini; V Porciatti; N Origlia; L Domenici |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-10 |
Journal Detail:
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Title: Brain research bulletin Volume: 82 ISSN: 1873-2747 ISO Abbreviation: Brain Res. Bull. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-06-23 Completed Date: 2010-10-06 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 7605818 Medline TA: Brain Res Bull Country: United States |
Other Details:
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Languages: eng Pagination: 169-76 Citation Subset: IM |
Copyright Information:
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Published by Elsevier Inc. |
Affiliation:
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Department of Neuroscience, Unit of Neurology, Pisa University Medical School, Pisa, Italy. f.sartucci@neuro.med.unipi.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Alzheimer Disease / physiopathology* Animals Electroretinography / methods* Evoked Potentials, Visual / physiology* Female Geniculate Bodies / physiopathology* Humans Male Photic Stimulation Visual Pathways / physiopathology* Visual Perception* |
| Grant Support | |
ID/Acronym/Agency:
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R01 EY014957-07/EY/NEI NIH HHS |
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