| Dysfunction of Ca2+/CaM kinase IIalpha cascades in the amygdala in post-traumatic stress disorder. | |
| | |
MedLine Citation:
|
PMID: 19885620 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Single-prolonged stress (SPS) is an established animal model for post-traumatic stress disorder (PTSD). The calcium (Ca2+)-calmodulin (CaM)-CaM kinase (K)IIalpha signal passage plays an important role in the plasticity of central nervous, learning and memory, mind and behavior and other types of cognitive activities. The amygdala is known to play an important role in fear, rage and emotional memory. In this study, we investigated changes in Ca2+-CaM-CaMKIIalpha in the basolateral amygdala of rats after SPS which may reveal part of the pathogenesis of PTSD. The intracellular free calcium level in the basolateral amygdala was examined by fluorescence spectrophotometry. CaM and CaMKIIalpha expression in basolateral amygdala was examined using immunohistochemistry, Western blotting and reverse transcription-polymerase chain reaction. The intracellular free calcium level in the basolateral amygdala was increased when compared to that in the control group 1 day after SPS exposure (P<0.05). CaM expression significantly increased, and CaMKIIalpha expression significantly decreased (P<0.05) in the basolateral amygdala after SPS. These findings suggest dysfunction of Ca2+-CaM-CaMKIIalpha in the basolateral amygdala of SPS rats, which may play important roles in the pathogenesis of PTSD rats. |
| | |
Authors:
|
Bing Xiao; Fang Han; Yu-Xiu Shi |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: International journal of molecular medicine Volume: 24 ISSN: 1791-244X ISO Abbreviation: Int. J. Mol. Med. Publication Date: 2009 Dec |
Date Detail:
|
Created Date: 2009-11-03 Completed Date: 2010-02-04 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9810955 Medline TA: Int J Mol Med Country: Greece |
Other Details:
|
Languages: eng Pagination: 795-9 Citation Subset: IM |
Affiliation:
|
Department of Histology and Embryology, Basic Medical Sciences College, China Medical University, Shenyang 110001, PR China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amygdala
/
enzymology*,
pathology Animals Blotting, Western Calcium / metabolism Calcium-Calmodulin-Dependent Protein Kinase Type 2 / genetics, metabolism* Calmodulin / genetics, metabolism Immunohistochemistry Intracellular Fluid / chemistry Male Rats Rats, Wistar Stress Disorders, Post-Traumatic / enzymology* Stress, Physiological / physiology Stress, Psychological / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Calmodulin; 7440-70-2/Calcium; EC 2.7.11.17/Calcium-Calmodulin-Dependent Protein Kinase Type 2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: REIC/Dkk-3 stable transfection reduces the malignant phenotype of mouse prostate cancer RM9 cells.
Next Document: Lambda-carrageenan oligosaccharides elicit reactive oxygen species production resulting in mitochond...