| Dysfunction in elastic fiber formation in fibulin-5 null mice abrogates the evolution in mechanical response of carotid arteries during maturation. | |
| | |
MedLine Citation:
|
PMID: 23241326 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Elastin fragmentation is a common characteristic of vascular diseases such as abdominal aortic aneurysms, peripheral arterial disease, and aortic dissection. Examining growth and remodeling in the presence of dysfunctional elastic fibers provides insight into the adaptive or maladaptive changes that tissues undergo in compensating for structural deficiencies. This study used the maturation of fibulin-5 knockout (KO) and wildtype (WT) mice to study the effects of fragmented elastic fibers on the growth and remodeling of carotid arteries. The microstructural content and organization and the biaxial mechanical behavior of common carotid arteries were measured and parameter estimation performed from KO and WT mice aged 3, 4, 8, and 13 weeks. Gross measurements and biaxial tests revealed significant differences in pressure-diameter behavior, in vivo axial stretch, opening angle, compliance, and wall stresses during maturation of wild-type arteries, but little change in these values in KO mice. Multiphoton microscopy used to image collagen fibers across the vessel wall in pressurized and stretched arteries suggests that there is little variation in fiber angles between different ages. Parameter estimation revealed significant differences in material parameters between genotypes and age groups. This study suggests that neonatal formation and cross-linking of functional elastic fibers, followed by increases in artery size due to growth with little remodeling of the elastic fibers, endow arteries with large distensibility and contributes to the evolution of mechanical behavior of arteries during maturation. Dysfunction in neonatal formation of elastic fibers abrogates many of the changes in mechanical response that take place during the maturation. |
| | |
Authors:
|
William Wan; Rudolph L Gleason |
Related Documents
:
|
22436646 - Clinical application of an original flexible mk stent-graft for nonruptured thoracic ao... 9079156 - Acid-base balance and o2 transport at high altitude. 2449416 - Role of substance p in hypercapnic excitation of carotid chemoreceptors. 7824186 - Influence of vagal afferents in the sneeze reflex in cats. 8754976 - Variants of shape of the pulmonary alveoli in corrosion casts in human lungs. 22075656 - Stenting of a gastroduodenal artery aneurysm: report of a case. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-12-15 |
Journal Detail:
|
Title: American journal of physiology. Heart and circulatory physiology Volume: - ISSN: 1522-1539 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2012 Dec |
Date Detail:
|
Created Date: 2012-12-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
1Georgia Institute of Technology. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pressure Overload Differentially Affects Respiratory Capacity in Interfibrillar and Subsarcolemmal M...
Next Document: Transcriptional repression by glycerol of genes involved in the assimilation of n-alkanes and fatty ...