| Dysfunction of human subcutaneous fat arterioles in obesity alone or obesity associated with Type 2 diabetes. | |
| | |
MedLine Citation:
|
PMID: 20979575 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
The aim of the present study was to examine the effects of obesity alone and obesity associated with Type 2 diabetes on the structure, vascular reactivity and response to insulin of isolated human subcutaneous fat arterioles; these effects were correlated with the expression of insulin signalling proteins. Periumbilical subcutaneous adipose tissue was explanted during surgery, small arterioles (internal diameter 220±40 μm) were dissected out and investigated by electron microscopy, myography and immunoblotting. Compared with the subcutaneous arterioles of lean subjects, obesity activated the endothelium, enhanced the accumulation of collagen within vascular wall and increased the sensitivity of adrenergic response; obesity also diminished eNOS (endothelial NO synthase) protein expression, NO production, and endothelium-dependent and insulin-induced vasodilatation, as well as the protein expression of both IRS (insulin receptor substrates)-1 and IRS-2 and of the downstream molecules in the insulin signalling pathway, such as PI3K (phosphoinositide 3-kinase), phospho-Akt and Akt. When obesity was associated with Type 2 diabetes, these changes were significantly augmented. In conclusion, obesity alone or obesity associated with Type 2 diabetes alters human periumbilical adipose tissue arterioles in terms of structure, function and biochemsitry, including diminished eNOS expression and reduced levels of IRS-1, IRS-2, PI3K and Akt in the insulin signalling pathway. |
| | |
Authors:
|
Adriana Georgescu; Doina Popov; Anamaria Constantin; Miruna Nemecz; Nicoleta Alexandru; Daniel Cochior; Aura Tudor |
Related Documents
:
|
9384185 - Assessment of overweight and obese patients. 2157655 - Beta-endorphin, insulin, acth and cortisol plasma levels during oral glucose tolerance ... 15999465 - The effect of orlistat-induced weight loss on interleukin-6 and c-reactive protein leve... 10385415 - Effect of diazoxide on brain capillary insulin receptor binding and food intake in hype... 14573875 - Chemical modification of insulin in amyloid fibrils. 20551625 - Preservation of kidney function with combined inhibition of nadph oxidase and angiotens... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Clinical science (London, England : 1979) Volume: 120 ISSN: 1470-8736 ISO Abbreviation: Clin. Sci. Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-01-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7905731 Medline TA: Clin Sci (Lond) Country: England |
Other Details:
|
Languages: eng Pagination: 463-72 Citation Subset: IM |
Affiliation:
|
†Institute of Cellular Biology and Pathology 'Nicolae Simionescu', Bucharest, Romania. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hereditary hemochromatosis: awareness and genetic testing acceptability in Western Romania.
Next Document: Identification of binding partners interacting with the ?1-N-propeptide of type V collagen.