Document Detail


Dysfunction of dopamine release in the prefrontal cortex of dysbindin deficient sandy mice: an in vivo microdialysis study.
MedLine Citation:
PMID:  20045719     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dystrobrevin binding protein-1 gene (DTNBP1), which encodes dysbindin protein, has been identified as a schizophrenia susceptibility gene. Dysbindin has been shown to contribute to the regulation of exocytosis and formation of synaptic vesicles. Although hypofrontality in schizophrenia underlies its pathophysiology, the molecular function of dysbindin in synaptic neurotransmission remains unclear. In the present study, we investigated depolarization-evoked dopamine (DA) and serotonin (5-HT) release in the prefrontal cortex (PFC) of sandy (sdy) mice, which have a deletion mutation in the gene encoding DTNBP1. In vivo microdialysis analysis revealed that extracellular DA levels in the PFC of wild-type mice were increased by 60mM KCl stimulation, and the KCl-evoked DA release was significantly decreased in sdy mice compared with wild-type mice. Extracellular 5-HT levels in the PFC of wild-type mice were also increased by 60mM KCl stimulation. The KCl-evoked 5-HT release did not differ between wild-type and sdy mice. There was no difference in basal levels of DA and 5-HT before the stimulation between two groups. Behavioral sensitization after repeated methamphetamine (METH) treatment was significantly reduced in sdy mice compared with wild-type mice whereas no difference was observed in METH-induced hyperlocomotion between two groups. These results suggest that dysbindin may have a role in the regulation of depolarization-evoked DA release in the PFC and in the development of behavioral sensitization induced by repeated METH treatment.
Authors:
Taku Nagai; Yuko Kitahara; Anna Shiraki; Takao Hikita; Shinichiro Taya; Kozo Kaibuchi; Kiyofumi Yamada
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-05
Journal Detail:
Title:  Neuroscience letters     Volume:  470     ISSN:  1872-7972     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-04-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  134-8     Citation Subset:  IM    
Copyright Information:
(c) 2010 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carrier Proteins / genetics,  metabolism*
Catheterization
Central Nervous System Agents / pharmacology
Dopamine / metabolism*
Dopamine Agents / pharmacology
Extracellular Space / drug effects,  metabolism
Membrane Potentials / drug effects
Methamphetamine / pharmacology
Mice
Mice, Inbred DBA
Microdialysis
Motor Activity / drug effects
Potassium Chloride / pharmacology
Prefrontal Cortex / drug effects,  metabolism*
Sequence Deletion
Serotonin / metabolism
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/Central Nervous System Agents; 0/Dopamine Agents; 0/Dtnbp1 protein, mouse; 50-67-9/Serotonin; 537-46-2/Methamphetamine; 7447-40-7/Potassium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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