| Dysfunction of astrocyte connexins 30 and 43 in dorsal lateral prefrontal cortex of suicide completers. | |
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MedLine Citation:
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PMID: 21571253 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Suicide is an important public health problem that results from the interaction of both psychosocial and biological factors. Although it is known that particular neurobiological processes underlie suicidal ideation and behavior, there still remains limited knowledge about the specific factors involved. METHODS: To explore the neurobiology of suicide we generated microarray data from dorsal lateral prefrontal cortex (DLPFC) in each of 28 male French-Canadian subjects (20 suicide completers). These results were followed up in a larger French-Canadian sample (n = 47, 38 suicide completers) and in microarray data available from the Stanley Foundation (n = 100, 36 suicide completers). To investigate the molecular mechanisms of this finding, we performed RNA interference and electrophoretic mobility shift assays. Animal behavioral experiments were done to control for drug and alcohol effects. RESULTS: We found reduced expression of Cx30 and Cx43 in DLPFC of suicide completers. We identified a previously unknown function for Sox9 as a transcription factor affecting expression of Cx30 in brain. CONCLUSIONS: These results suggest that alterations of astrocyte connexins might be involved in the suicide process and provide further evidence implicating astrocytes in psychopathology. |
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Authors:
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Carl Ernst; Corina Nagy; Sangyheon Kim; Jennie P Yang; Xiaoming Deng; Ian C Hellstrom; Kwang Ho Choi; Howard Gershenfeld; Michael J Meaney; Gustavo Turecki |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-05-14 |
Journal Detail:
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Title: Biological psychiatry Volume: 70 ISSN: 1873-2402 ISO Abbreviation: Biol. Psychiatry Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-07-27 Completed Date: 2011-11-29 Revised Date: 2012-01-12 |
Medline Journal Info:
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Nlm Unique ID: 0213264 Medline TA: Biol Psychiatry Country: United States |
Other Details:
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Languages: eng Pagination: 312-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Society of Biological Psychiatry. All rights reserved. |
Affiliation:
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McGill Group for Suicide Studies, McGill University, Montreal, Quebec, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Animals Astrocytes / metabolism* Cell Line, Transformed Connexin 43 / genetics, metabolism* Connexins / genetics, metabolism* Electrophoretic Mobility Shift Assay Female Gene Expression Regulation / genetics Humans Male Microarray Analysis / methods Middle Aged Prefrontal Cortex / pathology* Protein Binding / genetics Quebec / ethnology RNA, Small Interfering / genetics, metabolism Rats SOX9 Transcription Factor / genetics, metabolism Suicide* Time Factors Transfection / methods |
| Grant Support | |
ID/Acronym/Agency:
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MOP 79253//Canadian Institutes of Health Research |
| Chemical | |
Reg. No./Substance:
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0/Connexin 43; 0/Connexins; 0/GJB6 protein, human; 0/RNA, Small Interfering; 0/SOX9 Transcription Factor; 0/SOX9 protein, human |
| Comments/Corrections | |
Comment In:
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Biol Psychiatry. 2011 Aug 15;70(4):306-7
[PMID:
21791256
]
Biol Psychiatry. 2012 Jan 1;71(1):e1-2 [PMID: 21861987 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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