Document Detail

Dysconnectivity of multiple resting-state networks in patients with schizophrenia who have persistent auditory verbal hallucinations.
MedLine Citation:
PMID:  21791169     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Functional neuroimaging studies on schizophrenia have suggested abnormal task-related functional connectivity in patients with schizophrenia who have auditory verbal hallucinations (AVHs). However, little is known about intrinsic functional connectivity in these patients.
METHODS: Between January 2009 and February 2010, we studied patients with schizophrenia who had persistent and treatment-refractory AVHs in comparison with healthy controls. Using functional magnetic resonance imaging, we studied the functional connectivity of multiple resting state networks (RSNs) and their relation to symptom severity. We analyzed the data using a spatial group independent component analysis, and we used random-effects t tests to compare spatial components between groups.
RESULTS: There were 10 patients and 14 controls enrolled in this study. In total, 16 RSNs were identified, from which we selected 4 networks of interest for further analyses. Within a speech-related network, patients showed increased connectivity in bilateral temporal regions and decreased connectivity in the cingulate cortex. Within 2 additional RSNs associated with attention and executive control, respectively, patients exhibited abnormal connectivity in the precuneus and right lateral prefrontal areas. We found correlations between measures of AVH severity and functional connectivity of the left anterior cingulate, left superior temporal gyrus and right lateral prefrontal cortex.
LIMITATIONS: The relatively small sample size, the patients' use of antipsychotic medication and the lack of a clinical control group have to be considered as potential limitations.
CONCLUSION: Our findings indicate that disrupted intrinsic connectivity of a speech-related network could underlie persistent AVHs in patients with schizophrenia. In addition, the occurrence of hallucinatory symptoms seems to modulate RSNs associated with attention and executive control.
Nadine Donata Wolf; Fabio Sambataro; Nenad Vasic; Karel Frasch; Markus Schmid; Carlos Schönfeldt-Lecuona; Philipp Arthur Thomann; Robert Christian Wolf
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of psychiatry & neuroscience : JPN     Volume:  36     ISSN:  1488-2434     ISO Abbreviation:  J Psychiatry Neurosci     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-20     Completed Date:  2012-02-21     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  9107859     Medline TA:  J Psychiatry Neurosci     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  366-74     Citation Subset:  IM    
Copyright Information:
© 2011 Canadian Medical Association
Central Institute of Mental Health, Department of Addictive Behavior and Addiction Medicine, Mannheim, Germany.
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MeSH Terms
Case-Control Studies
Functional Neuroimaging / methods,  psychology*
Gyrus Cinguli / physiopathology*
Hallucinations / physiopathology*
Magnetic Resonance Imaging / methods,  psychology
Neural Pathways / physiopathology
Parietal Lobe / physiopathology*
Prefrontal Cortex / physiopathology*
Rest / physiology,  psychology
Schizophrenic Psychology*
Severity of Illness Index
Temporal Lobe / physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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