Document Detail


Dyschromatosis universalis hereditaria: two cases in a Chinese family.
MedLine Citation:
PMID:  16045675     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two cases of dyschromatosis universalis hereditaria (DUH) from a Chinese family are presented. Case 1 was a 62-year-old woman who had a generalized and progressive hyper- and hypopigmentation of the skin from the age of 8 years. Her brother had also developed a similar skin pigmentary defect from about the same age. Histopathological and ultrastructural examination of lesional skin showed increased melanin content in epidermal keratinocytes but no changes in the appearance or number of melanocytes. Although hereditary defects may influence melanogenesis resulting in a pigmentary anomaly, the pathogenesis of DUH remains unclear.
Authors:
G Wang; C-Y Li; T-W Gao; Y-F Liu
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical and experimental dermatology     Volume:  30     ISSN:  0307-6938     ISO Abbreviation:  Clin. Exp. Dermatol.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-07-27     Completed Date:  2005-11-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7606847     Medline TA:  Clin Exp Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  494-6     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an China. xjwgang@fmmu.edu.cn
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MeSH Terms
Descriptor/Qualifier:
Female
Humans
Hyperpigmentation / metabolism,  pathology*
Hypopigmentation / metabolism,  pathology*
Male
Melanins / analysis
Middle Aged
Siblings
Skin Diseases, Genetic / metabolism,  pathology*
Chemical
Reg. No./Substance:
0/Melanins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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