| Dynorphin modulates dopamine D1-receptor mediated turning behavior in 6-hydroxydopamine-lesioned rats. | |
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MedLine Citation:
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PMID: 10925169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated if the potentiated turning response to a challenge with the partial dopamine D1 receptor agonist SKF-38393, as seen after priming with L-dihydroxyphenylalanine (DOPA) of unilaterally 6-hydroxydopamine-lesioned rats, can be modulated by infusion of dynorphin A (1-17) in the striatum. Seventeen days after the 6-hydroxydopamine lesion, rats received intrastriatal dynorphin (0. 08 or 3.85 microg) followed by L-DOPA (50 mg/kg i.p.) and were challenged 3 days later with SKF-38393 (3.0 mg/kg s.c.). Compared to controls, the lower dose of dynorphin caused an earlier onset of turning, while the higher dose decreased the response to SKF-38393. These findings suggest a dose-dependent modulatory role for striatal dynorphin in L-DOPA-priming of a D1-mediated behavioral response. |
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Authors:
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S V van de Witte; H J Groenewegen; B Drukarch; P Voorn |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroscience letters Volume: 290 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 2000 Aug |
Date Detail:
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Created Date: 2000-10-06 Completed Date: 2000-10-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: IRELAND |
Other Details:
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Languages: eng Pagination: 37-40 Citation Subset: IM |
Affiliation:
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Research Institute Neurosciences, Vrije Universiteit, Department of Anatomy, van der Boechorststraat 7, 1081 BT, The, Amsterdam, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
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pharmacology* Adrenergic Agents / administration & dosage, pharmacology Animals Behavior, Animal / drug effects*, physiology* Dopamine Agonists / pharmacology* Dynorphins / administration & dosage, metabolism, physiology* Immunohistochemistry Injections, Intraventricular Male Oxidopamine / administration & dosage, pharmacology* Rats Rats, Wistar Receptors, Dopamine D1 / agonists, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic Agents; 0/Dopamine Agonists; 0/Receptors, Dopamine D1; 1199-18-4/Oxidopamine; 67287-49-4/2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 74913-18-1/Dynorphins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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