Document Detail


Dynapenia and aging: an update.
MedLine Citation:
PMID:  21444359     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In 2008, we published an article arguing that the age-related loss of muscle strength is only partially explained by the reduction in muscle mass and that other physiologic factors explain muscle weakness in older adults (Clark BC, Manini TM. Sarcopenia =/= dynapenia. J Gerontol A Biol Sci Med Sci. 2008;63:829-834). Accordingly, we proposed that these events (strength and mass loss) be defined independently, leaving the term "sarcopenia" to be used in its original context to describe the age-related loss of muscle mass. We subsequently coined the term "dynapenia" to describe the age-related loss of muscle strength and power. This article will give an update on both the biological and clinical literature on dynapenia-serving to best synthesize this translational topic. Additionally, we propose a working decision algorithm for defining dynapenia. This algorithm is specific to screening for and defining dynapenia using age, presence or absence of risk factors, a grip strength screening, and if warranted a test for knee extension strength. A definition for a single risk factor such as dynapenia will provide information in building a risk profile for the complex etiology of physical disability. As such, this approach mimics the development of risk profiles for cardiovascular disease that include such factors as hypercholesterolemia, hypertension, hyperglycemia, etc. Because of a lack of data, the working decision algorithm remains to be fully developed and evaluated. However, these efforts are expected to provide a specific understanding of the role that dynapenia plays in the loss of physical function and increased risk for disability among older adults.
Authors:
Todd M Manini; Brian C Clark
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-03-28
Journal Detail:
Title:  The journals of gerontology. Series A, Biological sciences and medical sciences     Volume:  67     ISSN:  1758-535X     ISO Abbreviation:  J. Gerontol. A Biol. Sci. Med. Sci.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-19     Completed Date:  2012-03-08     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  9502837     Medline TA:  J Gerontol A Biol Sci Med Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  28-40     Citation Subset:  AIM; IM    
Affiliation:
Institute on Aging and Department of Aging and Geriatric Research, University of Florida, Gainesville, FL 32611, USA. tmanini@aging.ufl.edu
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Aging / physiology*
Algorithms
Animals
Disabled Persons
Female
Geriatric Assessment
Hand Strength / physiology
Humans
Knee / innervation,  physiopathology
Male
Muscle Strength / physiology
Muscle Weakness / etiology*,  physiopathology
Muscle, Skeletal / innervation,  physiopathology
Rats
Risk Factors
Sarcopenia / classification*,  diagnosis,  physiopathology*
Translational Medical Research
Grant Support
ID/Acronym/Agency:
P30AG028740/AG/NIA NIH HHS; R15 HD065552-01/HD/NICHD NIH HHS; R15 HD065552-01S1/HD/NICHD NIH HHS; R15HD065552/HD/NICHD NIH HHS; R21AG031974/AG/NIA NIH HHS; UL1 TR000064/TR/NCATS NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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