| Dynamin I phosphorylation and the control of synaptic vesicle endocytosis. | |
| | |
MedLine Citation:
|
PMID: 15649133 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The GTPase dynamin I is essential for synaptic vesicle endocytosis in nerve terminals. It is a nerve terminal phosphoprotein that is dephosphorylated on nerve terminal stimulation by the calcium-dependent protein phosphatase calcineurin and then rephosphorylated by cyclin-dependent kinase 5 on termination of the stimulus. Because of its unusual phosphorylation profile, the phosphorylation status of dynamin I was assumed to be inexorably linked to synaptic vesicle endocytosis; however, direct proof of this link has been elusive until very recently. This review will describe current knowledge regarding dynamin I phosphorylation in nerve terminals and how this regulates its biological function with respect to synaptic vesicle endocytosis. |
| | |
Authors:
|
Karen J Smillie; Michael A Cousin |
Related Documents
:
|
14638853 - Cdk5 and the mystery of synaptic vesicle endocytosis. 7684513 - Tyrosine kinase-dependent selection of transmitter responses induced by neuronal contact. 7874203 - Regulation of the map kinase cascade. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Biochemical Society symposium Volume: - ISSN: 0067-8694 ISO Abbreviation: Biochem. Soc. Symp. Publication Date: 2005 |
Date Detail:
|
Created Date: 2005-01-14 Completed Date: 2005-03-31 Revised Date: 2012-06-25 |
Medline Journal Info:
|
Nlm Unique ID: 7506896 Medline TA: Biochem Soc Symp Country: England |
Other Details:
|
Languages: eng Pagination: 87-97 Citation Subset: IM |
Affiliation:
|
Membrane Biology Group, Division of Biomedical Sciences, University of Edinburgh, George Square, Edinburgh EH8 9XD, U.K. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amino Acid Sequence Animals Calcineurin / metabolism Cyclin-Dependent Kinase 5 Cyclin-Dependent Kinases / metabolism Dynamin I / chemistry, genetics, metabolism* Endocytosis / physiology* Humans Models, Neurological Molecular Sequence Data Molecular Structure Phosphorylation Protein Structure, Tertiary Synaptic Vesicles / physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
070569//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
|
EC 2.7.11.22/CDK5 protein, human; EC 2.7.11.22/Cyclin-Dependent Kinase 5; EC 2.7.11.22/Cyclin-Dependent Kinases; EC 3.1.3.16/Calcineurin; EC 3.5.1.50/Dynamin I |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Membrane traffic to and from lysosomes.
Next Document: Early endocytic Rabs: functional prediction to functional characterization.