Document Detail


Dynamics of sympathetic baroreflex control of arterial pressure in rats.
MedLine Citation:
PMID:  12794000     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
By a white noise approach, we characterized the dynamics of the sympathetic baroreflex system in 11 halothane-anesthetized rats. We measured sympathetic nerve activity (SNA) and systemic arterial pressure (SAP), while carotid sinus baroreceptor pressure (BRP) was altered randomly. We estimated the transfer functions from BRP to SNA (mechanoneural arc), from SNA to SAP (neuromechanical arc), and from BRP to SAP (total arc). The gain of the mechanoneural arc gradually increased about threefold as the frequency of BRP change increased from 0.01 to 0.8 Hz. In contrast, the gain of the neuromechanical arc rapidly decreased to 0.4% of the steady-state gain as the frequency increased from 0.01 to 1 Hz. Although the total arc also had low-pass characteristics, the rate of attenuation in its gain was significantly slower than that of the neuromechanical arc, reflecting the compensatory effect of the mechanoneural arc for the sluggish response of the neuromechanical arc. We conclude that the quantitative estimation of the baroreflex dynamics is vital for an integrative understanding of baroreflex function in rats.
Authors:
Takayuki Sato; Toru Kawada; Masashi Inagaki; Toshiaki Shishido; Masaru Sugimachi; Kenji Sunagawa
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  285     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-06-09     Completed Date:  2003-07-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R262-70     Citation Subset:  IM; S    
Affiliation:
Dept. of Cardiovascular Control, Kochi Medical School, Nankoku, Kochi 783-8505, Japan. tacsato-kochimed@umin.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Baroreflex / physiology*
Blood Pressure / physiology*
Carotid Body / physiology
Male
Models, Biological
Rats
Rats, Sprague-Dawley
Sympathetic Nervous System / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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