Document Detail


Dynamics of serum interleukin-6 level in patients with acute myocardial infarction.
MedLine Citation:
PMID:  11025249     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: Interleukin-6 (IL-6) is a key cytokine in the initiation of the acute-phase reaction that accompanies myocardial infarction. The study was designed to evaluate changes in serum IL-6 in patients with myocardial infarction and to compare IL-6 alterations with serum creatine kinase (CK) activity. Methods: Serum IL-6 level and CK activity were measured in 19 males with acute myocardial infarction. Blood was taken on the 1st, 3rd, 5th, 7th and 21st days of the disease. Control values were obtained from 30 age-matched healthy males. IL-6 was determined according to the ELISA method and CK was measured with a routine procedure. Results: Serum IL-6 was found to increase on the 1st and 3rd days of the disease, followed by some decline on days 5-21. However, the last values measured were still higher than those in the controls. Patients with transmural myocardial infarction had higher IL-6 levels than those with non-Q myocardial infarction. There was no difference in serum IL-6 in patients with myocardial infarction of the inferior cardiac wall and of the anterior cardiac wall. A correlation was found between IL-6 level and CK activity in the patients, especially on the 1st and 3rd days of the disease. Conclusion: Serum IL-6 increases in patients with myocardial infarction, and this elevation seems to be related to the mass of the affected myocardium. The highest increase is found during the first days of the disease, although the enhanced IL-6 level lasts for at least 3 weeks, probably reflecting the healing process of the myocardium. The clinical value of IL-6 determination does not seem to exceed that of the indices commonly used.
Authors:
Kucharz; Wilk
Related Documents :
2189569 - Optimised function for determining time to peak creatine kinase and creatine kinase-mb ...
1078299 - Serum iron, glutamic oxalacetic transaminase and creatine phosphokinase in acute myocar...
20609009 - Relationship between root caries and cardiac dysrhythmia.
16445599 - Accidental ten times overdose administration of recombinant human erythropoietin (rh-ep...
16424659 - Development of thalassaemic iron overload cardiomyopathy despite low liver iron levels ...
7295199 - Multivariate analyses of serum apolipoproteins and risk factors in relation to acute my...
21835319 - Electrocardiographic comparison of ventricular arrhythmias in patients with arrhythmoge...
14739729 - An update on electrical cardioversion of atrial fibrillation.
17437729 - Relation between leucocyte count, myonecrosis, myocardial perfusion, and outcomes follo...
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  European journal of internal medicine     Volume:  11     ISSN:  1879-0828     ISO Abbreviation:  Eur. J. Intern. Med.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-10-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9003220     Medline TA:  Eur J Intern Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  253-256     Citation Subset:  -    
Affiliation:
Department of Internal Medicine and Rheumatology, Medical University of Silesia, Al. Korfantego 28/86, PL 40-004, Katowice, Poland
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Diabetes mellitus and cancer.
Next Document:  Atherogen lipid profile in HIV-1-infected patients with lipodystrophy syndrome.