Document Detail

Dynamics and regulation of contractile actin-myosin networks in morphogenesis.
MedLine Citation:
PMID:  21130639     Owner:  NLM     Status:  MEDLINE    
Contractile actin-myosin networks generate forces that drive cell shape changes and tissue remodeling during development. These forces can also actively regulate cell signaling and behavior. Novel features of actin-myosin network dynamics, such as pulsed contractile behaviors and the regulation of myosin localization by tension, have been uncovered in recent studies of Drosophila. In vitro studies of single molecules and reconstituted protein networks reveal intrinsic properties of motor proteins and actin-myosin networks, while in vivo studies have provided insight into the regulation of their dynamics and organization. Analysis of the complex behaviors of actin-myosin networks will be crucial for understanding force generation in actively remodeling cells and the coordination of cell shape and movement at the tissue level.
Karen E Kasza; Jennifer A Zallen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-12-03
Journal Detail:
Title:  Current opinion in cell biology     Volume:  23     ISSN:  1879-0410     ISO Abbreviation:  Curr. Opin. Cell Biol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-21     Completed Date:  2011-05-25     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  8913428     Medline TA:  Curr Opin Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  30-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
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MeSH Terms
Actins / metabolism*
Biomechanical Phenomena
Myosins / metabolism*
Signal Transduction
Grant Support
R01 GM079340/GM/NIGMS NIH HHS; R01 GM079340/GM/NIGMS NIH HHS; R01 GM079340-05/GM/NIGMS NIH HHS; //Howard Hughes Medical Institute
Reg. No./Substance:
0/Actins; EC

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