| Dynamics of mitral regurgitation during nitroglycerin therapy: a Doppler echocardiographic study. | |
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MedLine Citation:
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PMID: 3092608 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Seven patients with decompensated chronic heart failure and functional mitral regurgitation were studied before and during administration of nitroglycerin at a mean dose of 42 micrograms/min (range 20 to 90 micrograms/min). Forward aortic flow obtained by pulsed Doppler increased significantly from 35 +/- 8 to 45 +/- 9 ml/beat (p less than 0.001) and correlated well with the cardiac output measured by thermodilution technique (r = 0.8). Whereas regurgitant mitral volume calculated from the difference between echocardiographic total stroke volume and forward aortic flow decreased significantly from 19 +/- 9 to 3 +/- 3 ml/beat (p less than 0.001), peak velocity of mitral regurgitant flow increased from 4.1 +/- 0.9 to 4.4 +/- 1.0 m/sec (p less than 0.05). The decrease in effective mitral regurgitation area derived from a modified Gorlin formula average 80%. Accordingly, in patients with decompensated chronic heart failure and functional mitral regurgitation, nitroglycerin decreases mitral regurgitant area substantially, and thus almost abolishes mitral regurgitation despite an increase in systolic pressure gradient between left ventricle and atrium. Moreover, the increase in forward flow can be entirely accounted for by the reduction in mitral regurgitant flow. |
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Authors:
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G Keren; A Bier; J A Strom; S Laniado; E H Sonnenblick; T H LeJemtel |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American heart journal Volume: 112 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 1986 Sep |
Date Detail:
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Created Date: 1986-09-29 Completed Date: 1986-09-29 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 517-25 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Echocardiography* Female Heart Failure / complications, drug therapy*, physiopathology Hemodynamics Humans Male Middle Aged Mitral Valve Insufficiency / complications, drug therapy*, physiopathology Nitroglycerin / therapeutic use* Ultrasonics |
| Chemical | |
Reg. No./Substance:
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55-63-0/Nitroglycerin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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