Document Detail

Dynamics of metabolic responses to prolonged elevation of circulating adrenaline in resting and exercising rats.
MedLine Citation:
PMID:  2928096     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to follow the time course of metabolic responses to hyperadrenalinemia sustained up to 3 days. Hyperadrenalinemia was produced in rats by s.c. implantation of tablets releasing adrenaline (A) at a constant rate (1.6 micrograms x min-1). After 6, 12, 24 and 72 h of hyperadrenalinemia and 3 days after the tablet removal rats were sacrificed and liver, 3 types of muscles and blood samples were taken. Each time 14 rats were used: 7 of them were sedentary and 7 performed treadmill endurance exercise before decapitation. Sham operated animals served as controls. In preliminary experiments working ability was examined in 10 hyperadrenalinemic and 10 control rats. Duration of exercise until exhaustion was reduced in hyperadrenalinemic rats on the average by 40%. In sedentary rats, hyperglycemia, marked depletion of liver glycogen (by approx. 80%) and muscle glycogen (by 60-80%) as well as an elevation (2-4 times) of muscle lactate (LA) were found only during the first day after A-tablet implantation. At the end of the experiment these values approached the control ones. Muscle contents of ATP and creatine phosphate (CrP) were decreased by approx. 20% and 30-60%, respectively. Plasma FFA were markedly enhanced, varying in the time-course of the experiment from 0.8 to 1.4 mmol x l-1. Post-exercise values for blood glucose, liver and muscle glycogen were always lower in hyperadrenalinemic rats than in controls sacrificed after time-matched exercise (30 min). Circulating FFA decreased during exercise at all time points following A-tablet implantation, but they were still above the post-exercise levels in sham-operated rats.(ABSTRACT TRUNCATED AT 250 WORDS)
K Nazar; H Kaciuba-Uściłko; S Porta; Z Brzezinska; J Langfort; W Pilis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  413     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-05-05     Completed Date:  1989-05-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  429-34     Citation Subset:  IM; S    
Department of Applied Physiology, Polish Academy of Sciences, Warsaw, Poland.
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MeSH Terms
Blood Glucose / metabolism*
Drug Implants
Epinephrine / administration & dosage,  blood*
Fatty Acids, Nonesterified / blood*
Liver Glycogen / metabolism*
Muscles / drug effects,  metabolism*
Physical Exertion*
Rats, Inbred Strains
Reg. No./Substance:
0/Blood Glucose; 0/Drug Implants; 0/Fatty Acids, Nonesterified; 0/Liver Glycogen; 51-43-4/Epinephrine

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