Document Detail


Dynamics of the membrana granulosa during expansion of the ovarian follicular antrum.
MedLine Citation:
PMID:  11165009     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
As an endocrine organ, the ovary has some unique characteristics. The formation, the maturation and the regression of the hormone producing cells really determine the timing, the amount and the type of hormone secreted. Here, we focus on the granulosa cells of ovarian follicles which express 17beta-hydroxysteroid dehydrogenase type 1 and cytochrome P450 aromatase. Follicles only produce estradiol late in follicular development before either ovulation or atresia ensues. We discuss the evidence that the membrana granulosa has many characteristics in common with other epithelia, including that it arises from stem cells. The corollary of this is that individual cells within the membrana granulosa are of different ages or stages of specialization. This is evident as regional differences across the membrana granulosa in terms of cell ages, shapes, gene expression, and even behaviour on cell death. We discuss theoretical considerations of the effects of antrum formation on the behavior of the membrana granulosa, and show evidence for differences between follicles in cell shapes, basal lamina phenotypes and location of younger cells, which we speculate is due to different rates of antrum expansion. Clearly, the membrana granulosa is dynamic, and this could explain much about the differences in the behaviors of cells from within the membrana granulosa, and between ovarian follicles.
Authors:
R J Rodgers; H F Irving-Rodgers; I L van Wezel; M Krupa; T C Lavranos
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Molecular and cellular endocrinology     Volume:  171     ISSN:  0303-7207     ISO Abbreviation:  Mol. Cell. Endocrinol.     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-05-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7500844     Medline TA:  Mol Cell Endocrinol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  41-8     Citation Subset:  IM    
Affiliation:
Department of Medicine, Flinders University of South Australia, Bedford Park, SA 5042, Australia. ray.rodgers@flinders.edu.au
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MeSH Terms
Descriptor/Qualifier:
17-Hydroxysteroid Dehydrogenases / metabolism
Animals
Aromatase / metabolism
Cell Division
Epithelial Cells / physiology
Estradiol / biosynthesis
Female
Follicular Fluid / physiology
Gene Expression
Granulosa Cells / cytology,  enzymology,  physiology*
Humans
Isoenzymes / metabolism
Ovarian Follicle / cytology,  physiology*
Phenotype
Telomerase / genetics
Chemical
Reg. No./Substance:
0/Isoenzymes; 50-28-2/Estradiol; EC 1.1.-/17-Hydroxysteroid Dehydrogenases; EC 1.14.14.1/Aromatase; EC 2.7.7.49/Telomerase

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