| Dynamics of the membrana granulosa during expansion of the ovarian follicular antrum. | |
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MedLine Citation:
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PMID: 11165009 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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As an endocrine organ, the ovary has some unique characteristics. The formation, the maturation and the regression of the hormone producing cells really determine the timing, the amount and the type of hormone secreted. Here, we focus on the granulosa cells of ovarian follicles which express 17beta-hydroxysteroid dehydrogenase type 1 and cytochrome P450 aromatase. Follicles only produce estradiol late in follicular development before either ovulation or atresia ensues. We discuss the evidence that the membrana granulosa has many characteristics in common with other epithelia, including that it arises from stem cells. The corollary of this is that individual cells within the membrana granulosa are of different ages or stages of specialization. This is evident as regional differences across the membrana granulosa in terms of cell ages, shapes, gene expression, and even behaviour on cell death. We discuss theoretical considerations of the effects of antrum formation on the behavior of the membrana granulosa, and show evidence for differences between follicles in cell shapes, basal lamina phenotypes and location of younger cells, which we speculate is due to different rates of antrum expansion. Clearly, the membrana granulosa is dynamic, and this could explain much about the differences in the behaviors of cells from within the membrana granulosa, and between ovarian follicles. |
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Authors:
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R J Rodgers; H F Irving-Rodgers; I L van Wezel; M Krupa; T C Lavranos |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Molecular and cellular endocrinology Volume: 171 ISSN: 0303-7207 ISO Abbreviation: Mol. Cell. Endocrinol. Publication Date: 2001 Jan |
Date Detail:
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Created Date: 2001-02-22 Completed Date: 2001-05-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7500844 Medline TA: Mol Cell Endocrinol Country: Ireland |
Other Details:
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Languages: eng Pagination: 41-8 Citation Subset: IM |
Affiliation:
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Department of Medicine, Flinders University of South Australia, Bedford Park, SA 5042, Australia. ray.rodgers@flinders.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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17-Hydroxysteroid Dehydrogenases
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metabolism Animals Aromatase / metabolism Cell Division Epithelial Cells / physiology Estradiol / biosynthesis Female Follicular Fluid / physiology Gene Expression Granulosa Cells / cytology, enzymology, physiology* Humans Isoenzymes / metabolism Ovarian Follicle / cytology, physiology* Phenotype Telomerase / genetics |
| Chemical | |
Reg. No./Substance:
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0/Isoenzymes; 50-28-2/Estradiol; EC 1.1.-/17-Hydroxysteroid Dehydrogenases; EC 1.14.14.1/Aromatase; EC 2.7.7.49/Telomerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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