Document Detail

Dynamics of the membrana granulosa during expansion of the ovarian follicular antrum.
MedLine Citation:
PMID:  11165009     Owner:  NLM     Status:  MEDLINE    
As an endocrine organ, the ovary has some unique characteristics. The formation, the maturation and the regression of the hormone producing cells really determine the timing, the amount and the type of hormone secreted. Here, we focus on the granulosa cells of ovarian follicles which express 17beta-hydroxysteroid dehydrogenase type 1 and cytochrome P450 aromatase. Follicles only produce estradiol late in follicular development before either ovulation or atresia ensues. We discuss the evidence that the membrana granulosa has many characteristics in common with other epithelia, including that it arises from stem cells. The corollary of this is that individual cells within the membrana granulosa are of different ages or stages of specialization. This is evident as regional differences across the membrana granulosa in terms of cell ages, shapes, gene expression, and even behaviour on cell death. We discuss theoretical considerations of the effects of antrum formation on the behavior of the membrana granulosa, and show evidence for differences between follicles in cell shapes, basal lamina phenotypes and location of younger cells, which we speculate is due to different rates of antrum expansion. Clearly, the membrana granulosa is dynamic, and this could explain much about the differences in the behaviors of cells from within the membrana granulosa, and between ovarian follicles.
R J Rodgers; H F Irving-Rodgers; I L van Wezel; M Krupa; T C Lavranos
Related Documents :
10515599 - Distribution of ganglioside gm3 in the rat ovary after gonadotropin stimulation.
339919 - Injected amphibian oocytes: a living test tube for the study of eukaryotic gene transcr...
11950339 - Synthesis and nkt cell stimulating properties of fluorophore- and biotin-appended 6"-am...
1036339 - Post ovulatory follicles of the domestic duck.
20149359 - The role of autophagy in follicular development and atresia in rat granulosa cells.
19342029 - The variable expression of lectin-like oxidized low-density lipoprotein receptor (lox-1...
12485839 - Expression of steroidogenic acute regulatory protein in cultured schwann cells and its ...
19420329 - Novel laminin 5 gamma 2-chain fragments potentiating the limbal epithelial cell outgrow...
9135999 - Genetic analysis of default mating behavior in saccharomyces cerevisiae.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Molecular and cellular endocrinology     Volume:  171     ISSN:  0303-7207     ISO Abbreviation:  Mol. Cell. Endocrinol.     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-05-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7500844     Medline TA:  Mol Cell Endocrinol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  41-8     Citation Subset:  IM    
Department of Medicine, Flinders University of South Australia, Bedford Park, SA 5042, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
17-Hydroxysteroid Dehydrogenases / metabolism
Aromatase / metabolism
Cell Division
Epithelial Cells / physiology
Estradiol / biosynthesis
Follicular Fluid / physiology
Gene Expression
Granulosa Cells / cytology,  enzymology,  physiology*
Isoenzymes / metabolism
Ovarian Follicle / cytology,  physiology*
Telomerase / genetics
Reg. No./Substance:
0/Isoenzymes; 50-28-2/Estradiol; EC 1.1.-/17-Hydroxysteroid Dehydrogenases; EC; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Crucial role of cytokines in sex steroid formation in normal and tumoral tissues.
Next Document:  StAR protein is increased by muscarinic receptor activation in human luteinized granulosa cells.