Document Detail


Dynamics of ion currents in the membrane of the isolated mollusc neuron under high pressure.
MedLine Citation:
PMID:  8823740     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The action of helium (up to 101 abs. atm.) under high pressure on ionic currents through the cellular membrane was studied in experiments on isolated neurons of a gastropod. A method of intracellular dialysis which is new for physiological investigations under hyperbaric conditions was used. A substantial decrease in the inward (sodium) current with increased pressure was found. Its amplitude was decreased by 10-15% at 25 abs. atm. and by 64% at 101 abs. atm. as compared with the control. At the same time, a shift in the currentvoltage characteristics along the abscissa was not observed. Significant changes in the outward (potassium) current were not appreciable. The inhibition of the sodium current observed in these experiments with increased pressure is associated with a possible change in the structure of the cell membrane under the influence of pressure; this leads in its turn to shifts in the functioning of the membrane components participating in the generation of the nerve impulse.
Authors:
V V Shushakov; I T Demchenko
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroscience and behavioral physiology     Volume:  26     ISSN:  0097-0549     ISO Abbreviation:  Neurosci. Behav. Physiol.     Publication Date:    1996 May-Jun
Date Detail:
Created Date:  1996-12-16     Completed Date:  1996-12-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0330471     Medline TA:  Neurosci Behav Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  241-4     Citation Subset:  IM; S    
Affiliation:
Laboratory of Hyperbaric Physiology, I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Saint Petersburg.
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MeSH Terms
Descriptor/Qualifier:
Air Pressure
Animals
Atmosphere Exposure Chambers
Cell Membrane / metabolism
Electrophysiology
Ion Channel Gating / physiology
Ion Channels / physiology*
Lymnaea / physiology*
Microdialysis
Neurons / metabolism*,  ultrastructure*
Patch-Clamp Techniques
Potassium Channels / physiology
Sodium Channels / metabolism
Chemical
Reg. No./Substance:
0/Ion Channels; 0/Potassium Channels; 0/Sodium Channels

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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