| Dynamics of insulin and glucagon secretion by the isolated perfused cat pancreas. | |
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MedLine Citation:
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PMID: 6125307 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The dynamics of insulin and glucagon secretion by the isolated perfused cat pancreas was studied in response to glucose and amino acid stimuli. 2. Insulin secretion is biphasic in response to either glucose or amino acid stimuli. 3. Glucose caused a much more pronounced first phase release than did a complete amino acid mixture; whereas glucose and the amino acid mixture stimulated late second phase insulin secretion equipotently. 4. The same amino acid mixture produced a biphasic secretion of glucagon characterized by a rapid and transient spike-release which was followed by a substantial, relatively steady-state, second secretory phase. 5. Various combinations of glucose and amino acids resulted in insulin secretion which suggests a simple additive stimuli phenomenon; whereas no such additive effect was observed with respect to amino acid stimulation of glucagon secretion. 6. Instead, various of the amino acids appear to stimulate maximal glucagon secretion independently. 7. Glucose failed to cause a suppression of amino acid induced glucagon release. 8. The quantitative aspects of this study suggest that the cat pancreas is very responsive to amino acid modulation of hormone release, a fact which may well reflect the high amino acid content of the cat's diet. |
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Authors:
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D L Curry; J G Morris; Q R Rogers; J S Stern |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Comparative biochemistry and physiology. A, Comparative physiology Volume: 72 ISSN: 0300-9629 ISO Abbreviation: Comp Biochem Physiol A Comp Physiol Publication Date: 1982 |
Date Detail:
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Created Date: 1982-10-29 Completed Date: 1982-10-29 Revised Date: 2008-10-30 |
Medline Journal Info:
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Nlm Unique ID: 1276312 Medline TA: Comp Biochem Physiol A Comp Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 333-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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pharmacology Animals Cats / metabolism* Female Glucagon / secretion* Glucose / pharmacology Insulin / secretion* Islets of Langerhans / drug effects, secretion* Male Perfusion / veterinary Rats / metabolism Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 11061-68-0/Insulin; 50-99-7/Glucose; 9007-92-5/Glucagon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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