Document Detail

Dynamics of injected somatostatin in blood of patients with hepatic failure and acromegaly.
MedLine Citation:
PMID:  6112735     Owner:  NLM     Status:  MEDLINE    
Plasma somatostatin levels were measured by radioimmunoassay (RIA) at various times after rapid injection into the blood of 4 patients with acromegaly, 4 patients with hepatic failure, and 4 healthy subjects. In contrast to the single peak found in normal and acromegalic individuals, two distinct peaks were observed in each patient with liver failure. The first occurred at about the same time as that observed in the other two groups, but the second occurred about 3 min later. This second peak could not be distinguished immunologically from the intact somatostatin tetradecapeptide. The half-time disappearance of somatostatin in patients with hepatic failure was significantly longer than in the normal subjects. Acromegalic subjects tended to have the shortest half-time disappearance of the injected somatostatin and the highest peak level. The results are consistent with the possibility that altered metabolism and/or binding of somatostatin occurs in hepatic failure and in acromegaly.
A J Kastin; A Arimura; D Gonzalez-Barcena; J Fishback; A V Schally; D H Coy
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Peptides     Volume:  1     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  1980  
Date Detail:
Created Date:  1981-07-20     Completed Date:  1981-07-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  257-9     Citation Subset:  IM    
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MeSH Terms
Acromegaly / blood*
Liver Cirrhosis, Alcoholic / blood*
Middle Aged
Somatostatin / blood*
Reg. No./Substance:

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