| Dynamics of glomerular ultrafiltration in the rat. VIII. Effects of hematocrit. | |
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MedLine Citation:
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PMID: 1111999 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was undertaken in an effort to examine the effects of selective variations in systemic hematocrit on the preglomerular, glomerular, and postglomerular micocirculation in the rat. By isovolemic exchange transfusions, systemic hematocrit (control 51 ml/100 ml) was either reduced (21 ml/100 ml, N equal 7 rats) or elevated (62 ml/100 ml, N equal 7). Single nephron glomerular filtration rate varied inversely and filtration fraction varied directly with the changes in hematocrit. The fall in filtration fraction with decreased hematocrit was due to a decline in the measured glomerular transcapillary hydraulic pressure difference and to a marked increased in the initial glomerular plasma flow rate. Afferent (RA)and efferent (RE) arteriolar resistance declined with the fall in hematocrit; RA fell proportionately more than did RE. The rise in filtration fraction with the elevation in hematocrit was due to a marked increase in in part due to a relatively greater rise in RE than in RA. These findings provide an attractive explanation for the general tendency for filtration fraction to vary directly with hematocrit in anemic and polycythemic states in man. |
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Authors:
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B D Myers; W M Deen; C R Robertson; B M Brenner |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Circulation research Volume: 36 ISSN: 0009-7330 ISO Abbreviation: Circ. Res. Publication Date: 1975 Mar |
Date Detail:
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Created Date: 1975-05-10 Completed Date: 1975-05-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0047103 Medline TA: Circ Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 425-35 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Exchange Transfusion, Whole Blood Glomerular Filtration Rate* Hematocrit* Kidney Glomerulus / physiology Mathematics Microcirculation Nephrons / physiology Rats Regional Blood Flow Vascular Resistance |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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