| Dynamics of fat absorption and effect of sham feeding on postprandial lipema. | |
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MedLine Citation:
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PMID: 20493191 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND & AIMS: Given the importance of postprandial hyperlipidemia to increase risk for atherosclerosis, in the present study, stable isotope-labeled meals were fed to healthy subjects (7 males and 3 females) to investigate the kinetics chylomicron synthesis and the effect of sensory exposure to lipid on metabolism. METHODS: Subjects performed two, 24-hour inpatient studies that entailed consumption of a liquid formula evening meal containing 30 g of oil (+ (13)C(2) triolein) on day 1. Breakfast (day 2) consisted of triacylglycerols (TAGs) fed as capsules (30 g oil + (13)C(7) triolein) to avoid activation of mouth taste receptors. Next, modified sham feeding of cream cheese occurred over 2 hours. In the 2 trials, the stimulus was either higher fat (HF) or lower fat (LF) cream cheese. A liquid meal was consumed at lunch. Blood sampling occurred intermittently, and chylomicron particles S(f) >400 TAGs were analyzed by gas chromatography-mass spectrometry. RESULTS: (13)C(2)-Label was found in fasting-state lipoproteins, and persons with higher body fat percentages showed greater dilution of meal TAGs from endogenous sources. For both trials, 13% ± 4% of lipoprotein TAGs oleic acid was derived from the previous evening meal. Incremental area under the curve for TAGs during HF was ∼2.5 times higher than after LF exposure (46 ± 15 vs 17 ± 5 μmol/L/h; P = .04). The greater HF morning lipemia occurred with elevated glucose, insulin, and nonesterified fatty acids peak after lunch. CONCLUSIONS: These data support a connection between enteral lipid metabolism and oral fat exposure, resulting in elevated postprandial lipemia. The results suggest that the intestine may participate in a mechanism coordinating oral fat signaling with control of subsequent macronutrient disposal in the body. |
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Authors:
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Rosa N Chavez-Jauregui; Richard D Mattes; Elizabeth J Parks |
Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural Date: 2010-05-19 |
Journal Detail:
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Title: Gastroenterology Volume: 139 ISSN: 1528-0012 ISO Abbreviation: Gastroenterology Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-01 Completed Date: 2010-11-30 Revised Date: 2011-11-01 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: United States |
Other Details:
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Languages: eng Pagination: 1538-48 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2010 AGA Institute. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9052, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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metabolism* Adult Atherosclerosis / etiology, metabolism, prevention & control Dietary Fats / pharmacokinetics* Enterocytes / metabolism Female Follow-Up Studies Gas Chromatography-Mass Spectrometry Humans Hyperlipidemias / complications, diet therapy, metabolism* Intestinal Absorption / physiology* Lipids / blood* Male Postprandial Period* Prognosis Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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1PL1DK081183-01/DK/NIDDK NIH HHS; 5R01 DK04520414/DK/NIDDK NIH HHS; 8 UL1 DE019584-02/DE/NIDCR NIH HHS; M01-RR00633/RR/NCRR NIH HHS; R01 DK063185-04/DK/NIDDK NIH HHS; R01 DK079913-03/DK/NIDDK NIH HHS; UL1RR024982/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Lipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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