Document Detail


Dynamics of dopamine and norepinephrine contents in the dorsal hippocampus of rats during immunization with dopamine conjugate.
MedLine Citation:
PMID:  18214284     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The dynamics of dopamine and norepinephrine contents in the dorsal hippocampus of rats immunized with a dopamine-BSA conjugate was studied during immobilization stress by mean of the microdialysis technique. Immunization with dopamine conjugate was accompanied by intensive production of antibodies against dopamine in rat blood and a tendency toward an increase in dopamine content in the dorsal hippocampus even in the basal state (before stress exposure). Under stress conditions, dopamine content in the dorsal hippocampus of immunized rats significantly increased. In control rats, stress was accompanied by a significant increase in norepinephrine content in the dorsal hippocampus. The observed peculiarities in dopamine and norepinephrine contents in the dorsal hippocampus of rats immunized with a dopamine conjugate were typical of active animals more resistant to emotional stress.
Authors:
A E Umriukhin; E V Diukareva; L A Vetrile; N A Trekova; A N Kravtsov; V A Evseev; K V Sudakov
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  143     ISSN:  0007-4888     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2008-01-24     Completed Date:  2008-03-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  399-402     Citation Subset:  IM    
Affiliation:
P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromatography, High Pressure Liquid
Dopamine / chemistry,  immunology,  metabolism*
Hippocampus / immunology,  metabolism*
Immunization / methods*
Male
Microdialysis
Norepinephrine / metabolism*
Rats
Rats, Wistar
Restraint, Physical
Serum Albumin, Bovine / chemistry,  immunology
Stress, Psychological / physiopathology
Chemical
Reg. No./Substance:
0/Serum Albumin, Bovine; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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