Document Detail

Dynamics of diastolic sounds caused by partially occluded coronary arteries.
MedLine Citation:
PMID:  19272945     Owner:  NLM     Status:  MEDLINE    
The aim of this project is to improve the detection of coronary occlusions using an approach based on the recording and analysis of isolated diastolic heart sounds associated with turbulent blood flow in occluded coronary arteries. The nonlinear dynamic analysis method based on approximate entropy has been proposed for the analysis of diastolic heart sounds. A commercially available electronic stethoscope was used to record the diastolic heart sounds from patients diagnosed with or without coronary artery disease (CAD) based on their coronary angiography examination. The nonlinear dynamical analysis (approximate entropy) measures of the diastolic heart sounds recorded from 30 patients with coronary occlusions and ten normal subjects were estimated. Results suggest the presence of the high nonlinear (approximate entropy) values of diastolic heart sounds associated with CAD (p < 0.05). This approach led to a sensitivity of 77%, a specificity of 80%, and an overall accuracy of 78%. As a summary, 23 out of 30 abnormal patients and eight out of ten normal patients were correctly detected.
Metin Akay; Yasemin M Akay; Dominique Gauthier; Robert G Paden; William Pavlicek; F David Fortuin; John P Sweeney; Richard W Lee
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2008-08-12
Journal Detail:
Title:  IEEE transactions on bio-medical engineering     Volume:  56     ISSN:  1558-2531     ISO Abbreviation:  IEEE Trans Biomed Eng     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-04-03     Completed Date:  2009-09-02     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0012737     Medline TA:  IEEE Trans Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  513-7     Citation Subset:  IM    
Harrington Department of Bioengineering, Ira Fulton School of Engineering, Arizona State University, Tempe, AZ 85287, USA.
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MeSH Terms
Coronary Artery Disease / diagnosis*
Coronary Occlusion / physiopathology*
Coronary Vessels / physiopathology*
Diagnostic Errors
Electronics, Medical / instrumentation
Heart Auscultation / instrumentation*
Heart Murmurs / physiopathology*
Nonlinear Dynamics
Sensitivity and Specificity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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