Document Detail

Dynamics of cohesin subunits in grasshopper meiotic divisions.
MedLine Citation:
PMID:  23283389     Owner:  NLM     Status:  Publisher    
The cohesin complex plays a key role for the maintenance of sister chromatid cohesion and faithful chromosome segregation in both mitosis and meiosis. This complex is formed by two structural maintenance of chromosomes protein family (SMC) subunits and two non-SMC subunits: an α-kleisin subunit SCC1/RAD21/REC8 and an SCC3-like protein. Several studies carried out in different species have revealed that the distribution of the cohesin subunits along the chromosomes during meiotic prophase I is not regular and that some subunits are distinctly incorporated at different cell stages. However, the accurate distribution of the different cohesin subunits in condensed meiotic chromosomes is still controversial. Here, we describe the dynamics of the cohesin subunits SMC1α, SMC3, RAD21 and SA1 during both meiotic divisions in grasshoppers. Although these subunits show a similar patched labelling at the interchromatid domain of metaphase I bivalents, SMCs and non-SMCs subunits do not always colocalise. Indeed, SA1 is the only cohesin subunit accumulated at the centromeric region of all metaphase I chromosomes. Additionally, non-SMC subunits do not appear at the interchromatid domain in either single X or B chromosomes. These data suggest the existence of several cohesin complexes during metaphase I. The cohesin subunits analysed are released from chromosomes at the beginning of anaphase I, with the exception of SA1 which can be detected at the centromeres until telophase II. These observations indicate that the cohesin components may be differentially loaded and released from meiotic chromosomes during the first and second meiotic divisions. The roles of these cohesin complexes for the maintenance of chromosome structure and their involvement in homologous segregation at first meiotic division are proposed and discussed.
A Calvente; A Viera; M T Parra; R de la Fuente; J A Suja; J Page; J L Santos; C García de la Vega; J L Barbero; J S Rufas
Related Documents :
22285019 - Molecular cytogenetic characterization of epithelioid hemangioendothelioma.
16191629 - Carotenoid availability affects the development of a colour-based mate preference and t...
22296109 - Optimisation of mesenchymal stromal cells karyotyping analysis: implications for clinic...
23570369 - Mapping heterotic loci for yield and agronomic traits using chromosome segment introgre...
24264819 - Identification and designation of telocentric chromosomes in barley by means of giemsa ...
24412089 - Withdrawn: corrigendum to "ring chromosome 21 presenting with sacrococcygeal teratoma: ...
21278389 - Deletions and rearrangements of the h19/igf2 enhancer region in patients with silver-ru...
15870329 - Reduced genetic variation occurs among genes of the highly clonal plant pathogen xantho...
3659269 - A microdosimetric interpretation of the radiobiological effectiveness of 125i and the p...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-4
Journal Detail:
Title:  Chromosoma     Volume:  -     ISSN:  1432-0886     ISO Abbreviation:  Chromosoma     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985138R     Medline TA:  Chromosoma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Departamento de Biología, Facultad de Ciencias, Edificio de Biológicas, Universidad Autónoma de Madrid, 28049, Madrid, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Surgical and radiologic anatomy of a cochleostomy produced via posterior tympanotomy for cochlear im...
Next Document:  Presence of an extra chromosome alters meiotic double-stranded break repair dynamics and MLH1 foci d...