| Dynamics of cervical remodeling during pregnancy and parturition: mechanisms and current concepts. | |
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MedLine Citation:
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PMID: 17205425 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cervix serves as a protective barrier from invading microorganisms and as a structural barrier to delivery of the fetus. Among all biological processes, the phenomenal connective tissue remodeling that occurs in the cervix during and after parturition is unparalleled in scope and magnitude. The process of connective tissue remodeling in the cervix during pregnancy occurs in four stages: softening, ripening, dilation, and repair. Although overlapping in time, each stage is uniquely regulated. Results from studies using serial measurements of cervical length indicate that cervical ripening precedes myometrial contractions of labor by several weeks, suggesting that parturition in women is a process of long duration and that uterine contractions of labor are late events in the parturition process. A clear understanding of the biologic mechanisms that regulate cervical remodeling during pregnancy is needed to influence the preterm birth rate and to develop strategies to prevent preterm dilation of the cervix. |
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Authors:
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R Ann Word; Xiang-Hong Li; Michael Hnat; Kelley Carrick |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Seminars in reproductive medicine Volume: 25 ISSN: 1526-8004 ISO Abbreviation: Semin. Reprod. Med. Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2007-01-05 Completed Date: 2007-04-05 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 100909394 Medline TA: Semin Reprod Med Country: United States |
Other Details:
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Languages: eng Pagination: 69-79 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9032, USA. Ruth.Word@UTSouthwestern.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cervical Ripening / physiology Cervix Uteri / anatomy & histology, physiology* Collagen / metabolism Connective Tissue / physiology Estrogens / physiology Female Humans Labor Stage, First / physiology Parturition / physiology* Pregnancy Progesterone / physiology Prostaglandins / physiology Receptors, Progesterone / physiology Relaxin / physiology |
| Grant Support | |
ID/Acronym/Agency:
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HD11149/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Estrogens; 0/Prostaglandins; 0/Receptors, Progesterone; 57-83-0/Progesterone; 9002-69-1/Relaxin; 9007-34-5/Collagen |
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