Document Detail

Dynamics of cerebral blood flow autoregulation in hypertensive patients.
MedLine Citation:
PMID:  11897244     Owner:  NLM     Status:  MEDLINE    
In hypertensive patients, the upper and lower limits of cerebral autoregulation are shifted to higher levels. However, the dynamics of cerebral autoregulation in hypertensive patients are less well known. We compared the dynamics of cerebral autoregulation in 21 treated hypertensive patients (13 men and 8 women; mean age: 48.9+/-13.6 years) and in 21 normotensive subjects (13 men and 8 women; mean age: 51+/-14.5 years) by transcranial Doppler (TCD) of the middle cerebral artery (MCA) during the acute decrease in blood pressure induced by standing up after 2 min in squatting position. MCA maximal outline blood flow velocity (FV), blood pressure (Finapres) and end-tidal PCO2 were continuously monitored and computerised. A cerebral vascular resistance index (CR) was calculated as follows: mean arterial BP/MCA mean FV with normalised changes in CR per second during the blood pressure decrease (CR slope). The CR slope reflecting the rate of cerebral autoregulation did not differ between the two groups and within the hypertensive patients [well controlled (8 patients) and not controlled (13 patients)]. The time to maximum decrease of CR (T1) and the time to full recovery of CR after the initial drop (T2) were also similar in the two groups (controls T1: 11.3+/-3.1 s, T2: 12+/-5.9 s; hypertensive T1: 11.7+/-2.5 s, T2: 10.7+/-4.5 s) and within hypertensive patients. These findings suggest that the dynamics of cerebral autoregulation are well preserved in hypertensive patients, with no difference according to the efficiency of treatment of hypertension.
Anne Pavy-Le Traon; Marie-Claude Costes-Salon; Michel Galinier; Joelle Fourcade; Vincent Larrue
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  195     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-18     Completed Date:  2002-05-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  139-44     Citation Subset:  IM    
Neurology Department, Rangueil Hospital, 1 Av. J. Poulhes, 31054 cedex, Toulouse, France.
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MeSH Terms
Blood Pressure / physiology
Brain / blood supply*,  physiopathology*
Cerebral Arteries / physiopathology*
Cerebrovascular Circulation / physiology*
Hemodynamics / physiology*
Homeostasis / physiology*
Hypertension / physiopathology*
Middle Aged
Reference Values
Erratum In:
J Neurol Sci 2002 Sep 15;201(1-2):91

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