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Dynamics of transcapillary fluid exchange.
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MedLine Citation:
PMID:  19873626     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Fluid balance at the capillary level has been simulated with an analogue computer program, based on experimental data on regional differences in capillary permeability, surface areas, and hydrostatic pressures. The program takes into account fluid and protein fluxes into and out of the interstitial space. Solutions are obtained for tissue hydrostatic pressure, tissue fluid osmotic pressure, interstitial space volume, and lymph flow. Simulation of a variety of physiological experiments and clinical disease states has yielded reasonable agreement between experimental data and data obtained by computer analysis. Dilution of the interstitial plasma protein pool with a consequent reduc6tion of its oncotic pressure appears to be a major factor, which prevents edema unless plasma oncotic pressures are reduced by 10-15 mm Hg or, alternatively, venous pressures are elevated by a similar amount. The computer analysis in all instances yields positive values for tissue pressure, in agreement with experimental data obtained by needle puncture. The negative tissue pressures observed in subcutaneous capsules can be reproduced in the computer program, if the interface between the capsule and the surrounding interstitial space is assumed to have the properties of a semipermeable membrane.
C A Wiederhielm
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of general physiology     Volume:  52     ISSN:  0022-1295     ISO Abbreviation:  J. Gen. Physiol.     Publication Date:  1968 Jul 
Date Detail:
Created Date:  2010-06-29     Completed Date:  2010-06-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985110R     Medline TA:  J Gen Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  29-63     Citation Subset:  -    
Microcirculation Laboratory, Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, Washington, 98105.
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Journal Information
Journal ID (nlm-ta): J Gen Physiol
ISSN: 0022-1295
ISSN: 1540-7748
Publisher: The Rockefeller University Press
Article Information
Copyright © 1968 by The Rockefeller University Press
Print publication date: Day: 1 Month: 7 Year: 1968
Volume: 52 Issue: 1
First Page: 29 Last Page: 63
ID: 2225779
PubMed Id: 19873626

Dynamics of Transcapillary Fluid Exchange
Curt A. Wiederhielm
From the Microcirculation Laboratory, Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, Washington, 98105

Article Categories:
  • Transcapillary Exchanges
    • Article

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