Document Detail

Dynamics of IgG1 and IgG2 subclass response in dogs naturally and experimentally infected with Ehrlichia canis.
MedLine Citation:
PMID:  11445156     Owner:  NLM     Status:  MEDLINE    
Immunoglobulin (Ig) G subclasses were measured in dogs naturally and experimentally infected with Ehrlichia canis using enzyme-linked immunosorbant assay (ELISA). In this study, a higher IgG2 subclass response was noticed to natural and experimental E. canis infection in dogs. Anti-E. canis-IgG2 optic density (OD) values were found to be significantly higher than anti-E. canis-IgG1 during the different phases of the disease, and no differences in the IgG subclass responses to E. canis infection were found between symptomatic and asymptomatic dogs. Doxycycline treatment, which eliminated the rickettsia in three of four persistently infected dogs, had no noticeable influence on the E. canis-IgG subclass OD values during the treatment period. In order to facilitate the study, an ELISA for the detection of anti-E. canis IgG was developed and was shown to be sensitive and specific for E. canis-IgG, and in a significant correlation with the indirect immunofluorescence antibody test.
S Harrus; T Waner; D Strauss-Ayali; H Bark; F Jongejan; G Hecht; G Baneth
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Veterinary parasitology     Volume:  99     ISSN:  0304-4017     ISO Abbreviation:  Vet. Parasitol.     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-07-10     Completed Date:  2001-10-04     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7602745     Medline TA:  Vet Parasitol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  63-71     Citation Subset:  IM    
Department of Clinical Sciences, School of Veterinary Medicine, Hebrew University of Jerusalem, PO Box 12, 76100, Rehovot, Israel.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use
Dog Diseases / drug therapy,  immunology*
Doxycycline / therapeutic use
Ehrlichia / immunology*
Ehrlichiosis / drug therapy,  immunology,  veterinary*
Enzyme-Linked Immunosorbent Assay / methods,  veterinary*
Fluorescent Antibody Technique, Indirect / veterinary
Immunoglobulin G / analysis,  biosynthesis*
Sensitivity and Specificity
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Immunoglobulin G; 564-25-0/Doxycycline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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