Document Detail


Dynamical quorum-sensing in oscillators coupled through an external medium.
MedLine Citation:
PMID:  23087494     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Many biological and physical systems exhibit population-density dependent transitions to synchronized oscillations in a process often termed "dynamical quorum sensing". Synchronization frequently arises through chemical communication via signaling molecules distributed through an external medium. We study a simple theoretical model for dynamical quorum sensing: a heterogenous population of limit-cycle oscillators diffusively coupled through a common medium. We show that this model exhibits a rich phase diagram with four qualitatively distinct physical mechanisms that can lead to a loss of coherent population-level oscillations, including a novel mechanism arising from effective time-delays introduced by the external medium. We derive a single pair of analytic equations that allow us to calculate phase boundaries as a function of population density and show that the model reproduces many of the qualitative features of recent experiments on BZ catalytic particles as well as synthetically engineered bacteria.
Authors:
David J Schwab; Ania Baetica; Pankaj Mehta
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Physica D. Nonlinear phenomena     Volume:  241     ISSN:  0167-2789     ISO Abbreviation:  Physica D     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9890573     Medline TA:  Physica D     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1782-1788     Citation Subset:  -    
Affiliation:
Dept. of Molecular Biology and Lewis-Sigler Institute, Princeton University, Princeton, NJ 08854.
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