Document Detail


Dynamical membrane curvature instability controlled by intermonolayer friction.
MedLine Citation:
PMID:  21709326     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
We study a dynamical curvature instability caused by a local chemical modification of a phospholipid membrane. In our experiments, a basic solution is microinjected close to a giant unilamellar vesicle, which induces a local chemical modification of some lipids in the external monolayer of the membrane. This modification causes a local deformation of the vesicle, which then relaxes. We present a theoretical description of this instability, taking into account both the change of the equilibrium lipid density and the change of the spontaneous membrane curvature induced by the chemical modification. We show that these two types of changes of the membrane properties yield different dynamics. In contrast, it is impossible to distinguish them when studying the equilibrium shape of a vesicle subjected to a global modification. In our model, the longest relaxation timescale is related to the intermonolayer friction, which plays an important part when there is a change in the equilibrium density in one monolayer. We compare our experimental results to the predictions of our model by fitting the measured time evolution of the deformation height to the solution of our dynamical equations. We obtain good agreement between theory and experiments. Our fits enable us to estimate the intermonolayer friction coefficient, yielding values that are consistent with previous measurements.
Authors:
Anne-Florence Bitbol; Jean-Baptiste Fournier; Miglena I Angelova; Nicolas Puff
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Publication Detail:
Type:  Journal Article     Date:  2011-06-27
Journal Detail:
Title:  Journal of physics. Condensed matter : an Institute of Physics journal     Volume:  23     ISSN:  1361-648X     ISO Abbreviation:  J Phys Condens Matter     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101165248     Medline TA:  J Phys Condens Matter     Country:  England    
Other Details:
Languages:  eng     Pagination:  284102     Citation Subset:  IM    
Affiliation:
Laboratoire Matière et Systèmes Complexes (MSC), Université Paris Diderot, Paris 7 and UMR CNRS 7057, 10 Rue Alice Domon et Léonie Duquet, F-75205 Paris Cedex 13, France.
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