| Dynamical Modeling of the Cell Cycle and Cell Fate Emergence in Caulobacter crescentus. | |
MedLine Citation:
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PMID: 25369202 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The division of Caulobacter crescentus, a model organism for studying cell cycle and differentiation in bacteria, generates two cell types: swarmer and stalked. To complete its cycle, C. crescentus must first differentiate from the swarmer to the stalked phenotype. An important regulator involved in this process is CtrA, which operates in a gene regulatory network and coordinates many of the interactions associated to the generation of cellular asymmetry. Gaining insight into how such a differentiation phenomenon arises and how network components interact to bring about cellular behavior and function demands mathematical models and simulations. In this work, we present a dynamical model based on a generalization of the Boolean abstraction of gene expression for a minimal network controlling the cell cycle and asymmetric cell division in C. crescentus. This network was constructed from data obtained from an exhaustive search in the literature. The results of the simulations based on our model show a cyclic attractor whose configurations can be made to correspond with the current knowledge of the activity of the regulators participating in the gene network during the cell cycle. Additionally, we found two point attractors that can be interpreted in terms of the network configurations directing the two cell types. The entire network is shown to be operating close to the critical regime, which means that it is robust enough to perturbations on dynamics of the network, but adaptable to environmental changes. |
Authors:
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César Quiñones-Valles; Ismael Sánchez-Osorio; Agustino Martínez-Antonio |
Publication Detail:
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Type: Journal Article Date: 2014-11-04 |
Journal Detail:
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Title: PloS one Volume: 9 ISSN: 1932-6203 ISO Abbreviation: PLoS ONE Publication Date: 2014 |
Date Detail:
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Created Date: 2014-11-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101285081 Medline TA: PLoS One Country: United States |
Other Details:
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Languages: eng Pagination: e111116 Citation Subset: IM |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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