Document Detail

Dynamic vs. fixed bag filling: impact on cardiac output rebreathing protocol.
MedLine Citation:
PMID:  20085827     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to compare the repeatability (2.77 multiplied by the within-subject SD)between two different rebreathing protocols on cardiac output ( ˙Q ), pulmonary diffusing capacity for carbon monoxide (DLCO) and nitric oxide (DLNO), and pulmonary capillary blood volume (Vc). This study compared two bag volume protocols [Fixed Bag Volume (FBV) = bag volume fixed at 60% of forced vital capacity; Dynamic Bag Volume (DBV) = bag volume matched to tidal volume at each stage of exercise].Ten females (age = 27±8 yrs; ˙VO2, (peak)=2.5±0.6 L/min had measurements at rest (12%), 52%, 88%, and 100% of ˙VO2, (peak) on two study days. Neither the slope nor intercept of ˙Q vs. ˙VO2 were different between either bag volume protocols. The slope of DLCO vs. ˙Q was the same but the intercept was higher for the FBV protocol. The bag volume affected the slope and the intercept between DLNO vs. ˙Q (p < 0.05).The mean repeatability was similar between both protocols for ˙Q (2.0 vs. 2.3 L/min) and DLCO (3.8 vs.5.9 mL/min/mmHg), regardless of exercise intensity. Increasing exercise intensity made the measurement error worse for Vc and DLNO (p ≤ 0.06). Measurement error was lower for Vc when using the FBV protocol (p = 0.02). Also, the pattern of bag volume used during rebreathing maneuvers affected the relation between DLNO vs. ˙Q more than it affected DLCO vs. ˙Q , or Vc vs. ˙Q. Additionally, the FBV protocol provided less measurement error for Vc compared to the DBV protocol [corrected].
Gerald S Zavorsky; Kenneth C Beck; Lauren M Cass; Raul Artal; Peter D Wagner
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Publication Detail:
Type:  Journal Article     Date:  2010-01-18
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  171     ISSN:  1878-1519     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-29     Completed Date:  2010-06-23     Revised Date:  2012-03-14    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  22-30     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier B.V. All rights reserved.
Department of Obstetrics, Gynecology and Women's Health, School of Medicine, Saint Louis University, Saint Mary's Health Center, Saint Louis MO 63117, USA.
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MeSH Terms
Carbon Monoxide / blood
Cardiac Output / physiology*
Exercise Test / methods
Middle Aged
Nitric Oxide / blood
Oxygen / blood
Oxygen Consumption
Pulmonary Diffusing Capacity*
Regression Analysis
Respiratory Function Tests / methods
Respiratory Mechanics / physiology*
Young Adult
Reg. No./Substance:
10102-43-9/Nitric Oxide; 630-08-0/Carbon Monoxide; 7782-44-7/Oxygen
Erratum In:
Respir Physiol Neurobiol. 2012 Mar 15;180(2-3):353-4

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