| Dynamic ventilation 3He MRI for the quantification of disease in the rat lung. | |
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MedLine Citation:
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PMID: 22167560 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Pulmonary diseases are known to be largely inhomogeneous. To evaluate such inhomogeneities, we are testing an image-based method to measure gas flow in the lung regionally. Dynamic, spin-density-weighted hyperpolarized 3He MR images performed during slow inhalation of this gas were analyzed to quantify regional inflation rate. This parameter was measured in ROIs that were defined by a rectangular grid that covered the entire rat lung and grew dynamically with it during its inflation. We used regional inflation rate to quantify elastase induced emphysema and to differentiate healthy (n=8) from elastase-treated (n=9) rat lungs as well as healthy from elastasetreated areas of one rat unilaterally treated with elastase in the left lung. Emphysema was also assessed by gold standard morphological and well-established hyperpolarized 3He MRI diffusion measurements. Mean values of regional inflation rates were significantly different for healthy and elastase-treated animals and correlated well with the apparent diffusion coefficient of 3He and morphological measurements. The image-based biomarker inflation rate may be useful for the assessment of regional lung ventilation. |
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Authors:
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A Kyriazis; I Rodriguez; N Nin; J L Izquierdo-Garcia; J-A Lorente Balanza; J M Perez Sanchez; J Pesic; L E Olsson; J Ruiz-Cabello |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-09 |
Journal Detail:
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Title: IEEE transactions on bio-medical engineering Volume: - ISSN: 1558-2531 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0012737 Medline TA: IEEE Trans Biomed Eng Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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