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Dynamic vascular changes following intravenous antibiotics in patients with cystic fibrosis.
MedLine Citation:
PMID:  22858239     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Adults with cystic fibrosis (CF) have altered large artery haemodynamics which is associated with a persisting systemic inflammatory state. We hypothesized that a short-term intervention favorably influencing the inflammatory status may modify their haemodynamic state. METHODS: Adult patients with CF were studied immediately preceding and following 2weeks of intravenous antibiotics. Large artery haemodynamics, principally heart rate-adjusted augmentation index (AIx) were obtained. Blood pressure (BP), spirometry and CRP were also measured. RESULTS: Complete data was available for 15 patients; mean (SD) age 28 (6)years. CRP was reduced while FEV(1)% predicted improved. Following treatment AIx was lower: 10.9 (10.9)% to 8.1 (10.9)% (p<0.05) while BP was similar and a trend toward lower heart rate (p=0.06). Change in AIx was related to baseline FEV(1)% predicted (r=0.77) and BMI (r=0.71) (both P<0.01). CONCLUSION: The abnormal central haemodynamics evident in adults with CF is modulated with a short intervention of intravenous antibiotics.
Authors:
James H Hull; Rachel Garrod; Timothy B Ho; Ronald K Knight; John R Cockcroft; Dennis J Shale; Charlotte E Bolton
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-1
Journal Detail:
Title:  Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society     Volume:  -     ISSN:  1873-5010     ISO Abbreviation:  J. Cyst. Fibros.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101128966     Medline TA:  J Cyst Fibros     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Affiliation:
Centre for Clinical Pharmacology, Division of Biomedical Sciences, St George's, University of London, Cranmer Terrace, London. SW17 0RE, UK.
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